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Comment
. 2021 Jan;93(1):197-198.
doi: 10.1002/jmv.26317. Epub 2020 Jul 27.

COVID-19: What type of cytokine storm are we dealing with?

Guillaume Monneret  1   2 , Ihsane Benlyamani  2 , Morgane Gossez  1   2 , Jesus F Bermejo-Martin  3   4 , Marta Martín-Fernandez  3   4 , Pierre Sesques  5 , Florent Wallet  6 , Fabienne Venet  1   2
Affiliations
Comment

COVID-19: What type of cytokine storm are we dealing with?

Guillaume Monneret et al. J Med Virol. 2021 Jan.
No abstract available

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Median/mean IL‐6 values in COVID‐19, septic shock, and cytokine release syndrome (CRS). Black horizontal lines depict medians for each group. CRS refers to cytokine release syndrome after CAR‐T cell infusion (at peaks of cytokine release). Values from recent/illustrative studies. COVID‐19 studies: Chen G et al. J Clin Invest. 2020;130:2620‐2629; Mo P et al. Clin Infect Dis. 2020 (Online); Zhou F. Lancet. 2020;395:1054‐1062; Zhu. Int J Infect Dis. 2020;95:332‐339; Monneret G et al. Intensive Care Med. 2020 (Online); Cai Q et al. Allergy. 2020; Gao Y et al. J Med Virol. 2020;92:791‐796; Qin C et al. Clin Infect Dis. 2020 (Online); Wang C et al. Intensive Care Med. 2020 (Online); Chen R et al. J Allergy Clin Immunol. 2020 (Online). CRS studies: Maude SL et al. N Engl J Med. 2014;371:1507‐1517; Lee DW et al. Blood. 2014;124:188‐195; Xu J et al. Proc Natl Acad Sci USA. 2019;116:9543‐9551; Teachey DT et al. Cancer Discov. 2016;6:664‐679; Hay KA et al. Blood. 2017;130:2295‐2306. Septic shock studies: Feng M et al. J Clin Lab Anal. 2016;30:1037‐1043; Song J et al. BMC Infect Dis. 2019;19:968; Tsalik EL et al. J Emerg Med. 2012;43:97‐106; Lin WC et al. PLoS One. 2017;12:e0178387; Ríos‐Toro JJ et al PLoS One. 2017;12:e0175254. Differences between groups were as follows: all groups (P < .0002, ANOVA), COVID‐19 vs septic shock (P < .002, Mann‐Whitney), COVID‐19 vs CRS (P < .002, Mann‐Whitney). ANOVA, analysis of variance; COVID, coronavirus disease; IL, interleukin‐6
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