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. 2020 Sep 1;202(5):756-759.
doi: 10.1164/rccm.202001-0179LE.

Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2

Yu Zhao  1 , Zixian Zhao  1 , Yujia Wang  1 , Yueqing Zhou  1 , Yu Ma  2 , Wei Zuo  1   3   4
Affiliations

Single-Cell RNA Expression Profiling of ACE2, the Receptor of SARS-CoV-2

Yu Zhao et al. Am J Respir Crit Care Med. .

Erratum in

No abstract available

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Figures

Figure 1.
Figure 1.
Single-cell RNA-sequencing analysis of normal human lungs. (A) Characteristics of lung transplant donors for single-cell RNA-sequencing analysis. (B) Cellular cluster map of the Asian male donor. All eight samples were analyzed using the Seurat R package. Cells were clustered using a graph-based, shared nearest-neighbor clustering approach and visualized using a t-distributed stochastic neighbor embedding plot. AT1 = type I alveolar; AT2 = type II alveolar; tSNE = t-distributed stochastic neighbor embedding.
Figure 2.
Figure 2.
Gene expression analysis in ACE2 (angiotensin-converting enzyme 2)-expressing type II alveolar (AT2) cell population. (A) Violin plots of expression for ACE2 and select cell type–specific marker genes significantly upregulated in distinct lung cell clusters from an Asian male donor. AGER is a type I alveolar cell marker, SFTPC (SPC) is an AT2 cell marker, SCGB3A2 is a club cell marker, TPPP3 is a ciliated cell marker, CD68 is a macrophage marker, and PTPRC (CD45) is a panimmune cell marker. (B) Dot plot of gene ontology enrichment analysis demonstrating enriched virus-related biological processes in the ACE2-expressing AT2 population. AT1 = type I alveolar; NK = natural killer.
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