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. 1988 Sep;73(3):430-5.

B lymphocyte activation in systemic lupus erythematosus: spontaneous production of IgG antibodies to DNA and environmental antigens in cultures of blood mononuclear cells

O Dar  1 , M R Salaman, M H Seifert, D A Isenberg
Affiliations

B lymphocyte activation in systemic lupus erythematosus: spontaneous production of IgG antibodies to DNA and environmental antigens in cultures of blood mononuclear cells

O Dar et al. Clin Exp Immunol. 1988 Sep.

Abstract

IgG antibodies to DNA, influenza virus haemagglutinin (HA), adenovirus hexon (HX) and mannan from Candida albicans (MN) have been determined in supernatants from 2-day unstimulated cultures of peripheral blood mononuclear cells from SLE patients and controls. Mean values were much higher in the SLE group, with from 20% (MN) to 85% (DNA) of patients giving values above the normal range. Although a significant correlation was observed between anti-DNA and anti-HA production, anti-HX and anti-MN showed no such correlations. The specificity of the ELISA assays was demonstrated by inhibition tests. It is concluded that a selective form of polyclonal activation in SLE results in the production of antibodies to foreign as well as to self antigens.

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References

    1. Ann Intern Med. 1968 Oct;69(4):749-56 - PubMed
    1. Ann Intern Med. 1975 Nov;83(5):709-15 - PubMed
    1. Arthritis Rheum. 1977 Apr;20(3):829-33 - PubMed
    1. Arthritis Rheum. 1978 Nov-Dec;21(8):873-9 - PubMed
    1. Clin Exp Immunol. 1979 Jan;35(1):76-88 - PubMed

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