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. 2020 May 20:11:461.
doi: 10.3389/fpsyt.2020.00461. eCollection 2020.

Imaging of Morphological Background in Selected Functional and Inflammatory Gastrointestinal Diseases in fMRI

Katarzyna Skrobisz  1 , Grazyna Piotrowicz  2 , Patrycja Naumczyk  3 , Agnieszka Sabisz  4 , Karolina Markiet  4 , Grazyna Rydzewska  5 , Edyta Szurowska  4
Affiliations

Imaging of Morphological Background in Selected Functional and Inflammatory Gastrointestinal Diseases in fMRI

Katarzyna Skrobisz et al. Front Psychiatry. .

Abstract

The study focuses on evaluation of the Default Mode Network (DMN) activity in functional magnetic resonance imaging (fMRI) in resting state in patients with functional dyspepsia (FD) and irritable bowel syndrome (IBS), Crohn's disease and colitis ulcerosa (IBD) in comparison to healthy volunteers. We assume that etiology of both functional and non-specific inflammatory bowel diseases is correlated with disrupted structure of axonal connections. We would like to identify the network of neuronal connections responsible for presentation of symptoms in these diseases. 56 patients (functional dyspepsia, 18; Crohn's disease and colitis ulcerosa, 18; irritable bowel syndrome, 20) and 18 healthy volunteers underwent examination in MRI of the brain with assessment of brain morphology and central nervous system activity in functional imaging in resting state performed in 3T scanner. Compared to healthy controls' DMN in patients with non-specific digestive tract diseases comprised additional areas in superior frontal gyrus of left hemisphere, in left cingulum and in the left supplementary motor area. Discovered differences in the DMNs can be interpreted as altered processing of homeostatic stimuli. Our study group involved patients suffering from both functional and non-specific inflammatory bowel diseases. Nevertheless a spectrum of changes in the study group (superior frontal gyrus of the left hemisphere, in the left cingulum and in the left supplementary motor area) we were able to find common features, differentiating the whole study group from the healthy controls.

Keywords: functional dyspepsia (fd); functional magnetic resonance imaging (fMRI); inflammatory bowel diseases; irritable bowel syndrome (IBS); resting-state.

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Figures

Figure 1
Figure 1
(A) Significant (cluster corrected pFDR < .05) clusters of intergroup comparisons in contrast with the control group. The red cluster defines area of additional DMN connectivity of the IBD group, the green cluster represents a region of auxiliary connectivity of the DMN shared by both FD and IBS groups, whereas the yellow clusters underpin regions of increased DMN connectivity shared by all of the gastrointestinal diseases. (B) A map of the main effect of the Default Mode Network as reconstructed during the Independent Component Analysis across all of the subjects—patients and controls combined (pFWE < 0.05). CON, the control group; FD, the functional dyspepsia group; IBS, the irritable bowel syndrome group; IBD, the inflammatory bowel disease group; ALL, all diseases (FD, IBS, and IBD).
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