Dysregulation of type I interferon responses in COVID-19

doi:10.1038/s41577-020-0346-x

. 2020 Jul;20(7):397-398.

doi: 10.1038/s41577-020-0346-x. Epub 2020 May 26.

Dysregulation of type I interferon responses in COVID-19

Dhiraj Acharya¹, GuanQun Liu¹, Michaela U Gack²

Affiliations

¹ Department of Microbiology, The University of Chicago, Chicago, IL, USA.
² Department of Microbiology, The University of Chicago, Chicago, IL, USA. mgack@uchicago.edu.

PMID: 32457522
PMCID: PMC7249038
DOI: 10.1038/s41577-020-0346-x

Dysregulation of type I interferon responses in COVID-19

Dhiraj Acharya et al. Nat Rev Immunol. 2020 Jul.

. 2020 Jul;20(7):397-398.

doi: 10.1038/s41577-020-0346-x. Epub 2020 May 26.

Authors

Dhiraj Acharya¹, GuanQun Liu¹, Michaela U Gack²

Affiliations

¹ Department of Microbiology, The University of Chicago, Chicago, IL, USA.
² Department of Microbiology, The University of Chicago, Chicago, IL, USA. mgack@uchicago.edu.

PMID: 32457522
PMCID: PMC7249038
DOI: 10.1038/s41577-020-0346-x

Abstract

Infection with SARS-CoV-2 can lead to excessive production of pro-inflammatory cytokines, but the production of type I interferons, which are key antiviral mediators, is reportedly blunted. Here, we discuss how imbalanced interferon responses may contribute to the pathology of COVID-19.

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Conflict of interest statement

The authors declare no competing interests.

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References

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1. Hadjadj J, et al. Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients. Preprint at medRxiv. 2020 doi: 10.1101/2020.04.19.20068015. - DOI - PMC - PubMed
1. Zhou Z, et al. Heightened innate immune responses in the respiratory tract of COVID-19 patients. Cell Host Microbe. 2020 doi: 10.1016/j.chom.2020.04.017. - DOI - PMC - PubMed
1. Cameron MJ, et al. Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J. Virol. 2007;81:8692–8706. doi: 10.1128/JVI.00527-07. - DOI - PMC - PubMed
1. Channappanavar R, et al. Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice. Cell Host Microbe. 2016;19:181–193. doi: 10.1016/j.chom.2016.01.007. - DOI - PMC - PubMed

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[1] Blanco-Melo D, et al. Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell. 2020 doi: 10.1016/j.cell.2020.04.026. - DOI - PMC - PubMed

[2] Blanco-Melo D, et al. Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell. 2020 doi: 10.1016/j.cell.2020.04.026. - DOI - PMC - PubMed

[3] Hadjadj J, et al. Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients. Preprint at medRxiv. 2020 doi: 10.1101/2020.04.19.20068015. - DOI - PMC - PubMed

[4] Hadjadj J, et al. Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients. Preprint at medRxiv. 2020 doi: 10.1101/2020.04.19.20068015. - DOI - PMC - PubMed

[5] Zhou Z, et al. Heightened innate immune responses in the respiratory tract of COVID-19 patients. Cell Host Microbe. 2020 doi: 10.1016/j.chom.2020.04.017. - DOI - PMC - PubMed

[6] Zhou Z, et al. Heightened innate immune responses in the respiratory tract of COVID-19 patients. Cell Host Microbe. 2020 doi: 10.1016/j.chom.2020.04.017. - DOI - PMC - PubMed

[7] Cameron MJ, et al. Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J. Virol. 2007;81:8692–8706. doi: 10.1128/JVI.00527-07. - DOI - PMC - PubMed

[8] Cameron MJ, et al. Interferon-mediated immunopathological events are associated with atypical innate and adaptive immune responses in patients with severe acute respiratory syndrome. J. Virol. 2007;81:8692–8706. doi: 10.1128/JVI.00527-07. - DOI - PMC - PubMed

[9] Channappanavar R, et al. Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice. Cell Host Microbe. 2016;19:181–193. doi: 10.1016/j.chom.2016.01.007. - DOI - PMC - PubMed

[10] Channappanavar R, et al. Dysregulated type I interferon and inflammatory monocyte-macrophage responses cause lethal pneumonia in SARS-CoV-infected mice. Cell Host Microbe. 2016;19:181–193. doi: 10.1016/j.chom.2016.01.007. - DOI - PMC - PubMed

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Dysregulation of type I interferon responses in COVID-19

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Dysregulation of type I interferon responses in COVID-19

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