Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?

doi:10.1183/13993003.01560-2020

Comment

. 2020 Jul 16;56(1):2001560.

doi: 10.1183/13993003.01560-2020. Print 2020 Jul.

Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?

Dhamend Lutchman¹

Affiliations

PMID: 32398309
PMCID: PMC7236827
DOI: 10.1183/13993003.01560-2020

Comment

Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?

Dhamend Lutchman. Eur Respir J. 2020.

. 2020 Jul 16;56(1):2001560.

doi: 10.1183/13993003.01560-2020. Print 2020 Jul.

Author

Dhamend Lutchman¹

Affiliation

¹ Point Cook, Mebourne, Australia dlutchman@yahoo.com.

PMID: 32398309
PMCID: PMC7236827
DOI: 10.1183/13993003.01560-2020

Abstract

Exogenous supplement of recombinant human (rh)ACE-2 might be a brilliant idea in the treatment of COVID-19. Soluble ACE-2 might impact viral spread, since binding to soluble receptor has been shown to block SARS-CoV-2 entry. https://bit.ly/3bsUKO2

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Conflict of interest statement

Conflict of interest: D. Lutchman has nothing to disclose.

Comment in

Smoking, ACE-2 and COVID-19: ongoing controversies.
Leung JM, Sin DD. Leung JM, et al. Eur Respir J. 2020 Jul 16;56(1):2001759. doi: 10.1183/13993003.01759-2020. Print 2020 Jul. Eur Respir J. 2020. PMID: 32430431 Free PMC article.

Comment on

ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19.
Leung JM, Yang CX, Tam A, Shaipanich T, Hackett TL, Singhera GK, Dorscheid DR, Sin DD. Leung JM, et al. Eur Respir J. 2020 May 14;55(5):2000688. doi: 10.1183/13993003.00688-2020. Print 2020 May. Eur Respir J. 2020. PMID: 32269089 Free PMC article.
COVID-19 and smoking: is nicotine the hidden link?
Russo P, Bonassi S, Giacconi R, Malavolta M, Tomino C, Maggi F. Russo P, et al. Eur Respir J. 2020 Jun 4;55(6):2001116. doi: 10.1183/13993003.01116-2020. Print 2020 Jun. Eur Respir J. 2020. PMID: 32341101 Free PMC article.
COVID-19 and nicotine as a mediator of ACE-2.
Leung JM, Yang CX, Sin DD. Leung JM, et al. Eur Respir J. 2020 Jun 4;55(6):2001261. doi: 10.1183/13993003.01261-2020. Print 2020 Jun. Eur Respir J. 2020. PMID: 32350104 Free PMC article.

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Tsigaris P, Teixeira da Silva JA. Tsigaris P, et al. Nicotine Tob Res. 2020 Aug 24;22(9):1646-1649. doi: 10.1093/ntr/ntaa121. Nicotine Tob Res. 2020. PMID: 32609839 Free PMC article.
Cardiovascular manifestations secondary to COVID-19: A narrative review.
Fauvel C, Trimaille A, Weizman O, Pezel T, Mika D, Waldmann V, Cohen A, Bonnet G. Fauvel C, et al. Respir Med Res. 2022 May;81:100904. doi: 10.1016/j.resmer.2022.100904. Epub 2022 May 4. Respir Med Res. 2022. PMID: 35525097 Free PMC article. Review.
Multiple Neuroinvasive Pathways in COVID-19.
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Gupta I, Sohail MU, Elzawawi KE, Amarah AH, Vranic S, Al-Asmakh M, Al Moustafa AE. Gupta I, et al. Comput Struct Biotechnol J. 2021;19:1654-1660. doi: 10.1016/j.csbj.2021.03.023. Epub 2021 Mar 23. Comput Struct Biotechnol J. 2021. PMID: 33777332 Free PMC article. Review.
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Gupta AK, Nethan ST, Mehrotra R. Gupta AK, et al. Respir Med. 2021 Jan;176:106233. doi: 10.1016/j.rmed.2020.106233. Epub 2020 Nov 19. Respir Med. 2021. PMID: 33253975 Free PMC article. Review.

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References

1. Russo P, Bonassi S, Giacconi R, et al. . COVID-19 and smoking: is nicotine the hidden link? Eur Respir J 2020; 55: 2001116. doi:10.1183/13993003.01116-2020 - DOI - PMC - PubMed
1. Leung JM, Yang CX, Sin DD. COVID-19 and nicotine as a mediator of ACE-2. Eur Respir J 2020; 55: 2001261. doi:10.1183/13993003.01261-2020 - DOI - PMC - PubMed
1. Olds JL, Kabbani N. Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population? FEBS J 2020; in press [https://doi.org/10.1111/febs.15303]. doi:10.1111/febs.15303 - DOI - PMC - PubMed
1. Changeux JP, Amoura Z, Rey F, et al. . A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. Qeios 2020; preprint [https://doi.org/10.32388/FXGQSB]. doi:10.32388/FXGQSB - DOI - PubMed
1. Berlin I, Thomas D, Le Faou AL, et al. . COVID-19 and smoking. Nicotine Tob Res 2020; in press [https://doi.org/10.1093/ntr/ntaa059]. doi:10.1093/ntr/ntaa059 - DOI - PMC - PubMed

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[1] Russo P, Bonassi S, Giacconi R, et al. . COVID-19 and smoking: is nicotine the hidden link? Eur Respir J 2020; 55: 2001116. doi:10.1183/13993003.01116-2020 - DOI - PMC - PubMed

[2] Russo P, Bonassi S, Giacconi R, et al. . COVID-19 and smoking: is nicotine the hidden link? Eur Respir J 2020; 55: 2001116. doi:10.1183/13993003.01116-2020 - DOI - PMC - PubMed

[3] Leung JM, Yang CX, Sin DD. COVID-19 and nicotine as a mediator of ACE-2. Eur Respir J 2020; 55: 2001261. doi:10.1183/13993003.01261-2020 - DOI - PMC - PubMed

[4] Leung JM, Yang CX, Sin DD. COVID-19 and nicotine as a mediator of ACE-2. Eur Respir J 2020; 55: 2001261. doi:10.1183/13993003.01261-2020 - DOI - PMC - PubMed

[5] Olds JL, Kabbani N. Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population? FEBS J 2020; in press [https://doi.org/10.1111/febs.15303]. doi:10.1111/febs.15303 - DOI - PMC - PubMed

[6] Olds JL, Kabbani N. Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population? FEBS J 2020; in press [https://doi.org/10.1111/febs.15303]. doi:10.1111/febs.15303 - DOI - PMC - PubMed

[7] Changeux JP, Amoura Z, Rey F, et al. . A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. Qeios 2020; preprint [https://doi.org/10.32388/FXGQSB]. doi:10.32388/FXGQSB - DOI - PubMed

[8] Changeux JP, Amoura Z, Rey F, et al. . A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. Qeios 2020; preprint [https://doi.org/10.32388/FXGQSB]. doi:10.32388/FXGQSB - DOI - PubMed

[9] Berlin I, Thomas D, Le Faou AL, et al. . COVID-19 and smoking. Nicotine Tob Res 2020; in press [https://doi.org/10.1093/ntr/ntaa059]. doi:10.1093/ntr/ntaa059 - DOI - PMC - PubMed

[10] Berlin I, Thomas D, Le Faou AL, et al. . COVID-19 and smoking. Nicotine Tob Res 2020; in press [https://doi.org/10.1093/ntr/ntaa059]. doi:10.1093/ntr/ntaa059 - DOI - PMC - PubMed

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Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?

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Could the smoking gun in the fight against COVID-19 be the (rh)ACE-2?

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