Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

doi:10.1016/j.virusres.2020.197980

Review

. 2020 Sep:286:197980.

doi: 10.1016/j.virusres.2020.197980. Epub 2020 Apr 18.

Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

Tong-Qing An¹, Jiang-Nan Li¹, Chia-Ming Su², Dongwan Yoo³

Affiliations

¹ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
² Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA.
³ Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA. Electronic address: dyoo@llinois.edu.

PMID: 32311386
PMCID: PMC7165118
DOI: 10.1016/j.virusres.2020.197980

Review

Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

Tong-Qing An et al. Virus Res. 2020 Sep.

. 2020 Sep:286:197980.

doi: 10.1016/j.virusres.2020.197980. Epub 2020 Apr 18.

Authors

Tong-Qing An¹, Jiang-Nan Li¹, Chia-Ming Su², Dongwan Yoo³

Affiliations

¹ State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, 150069, China.
² Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA.
³ Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA. Electronic address: dyoo@llinois.edu.

PMID: 32311386
PMCID: PMC7165118
DOI: 10.1016/j.virusres.2020.197980

Abstract

Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral system and provide favorable conditions for survival. The current study reviews viral strategies for modulations of cellular processes including innate immunity, apoptosis, microRNAs, inflammatory cytokines, and other cellular pathways.

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References

1. Ahmad A., Sharif-Askari E., Fawaz L., Menezes J. Innate Immune Response of the Human Host to Exposure with Herpes Simplex Virus Type 1: In Vitro Control of the Virus Infection by Enhanced Natural Killer Activity via Interleukin-15 Induction. J. Virol. 2000;74:7196–7203. doi: 10.1128/JVI.74.16.7196-7203.2000. - DOI - PMC - PubMed
1. Albina E., Carrat C., Charley B. Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. J. Interf. cytokine Res. 1998;18:485–490. doi: 10.1089/jir.1998.18.485. - DOI - PubMed
1. Benfield D.A., Nelson E., Collins J.E., Harris L., Goyal S.M., Robison D., Christianson W.T., Morrison R.B., Gorcyca D., Chladek D. Characterization of Swine Infertility and Respiratory Syndrome (SIRS) Virus (Isolate ATCC VR-2332) J. Vet. Diagnostic Investig. 1992;4:127–133. doi: 10.1177/104063879200400202. - DOI - PubMed
1. Beura L.K., Sarkar S.N., Kwon B., Subramaniam S., Jones C., Pattnaik A.K., Osorio F.A. Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1β Modulates Host Innate Immune Response by Antagonizing IRF3 Activation. J. Virol. 2010;84:1574–1584. doi: 10.1128/JVI.01326-09. - DOI - PMC - PubMed
1. Bi J., Song S., Fang L., Wang D., Jing H., Gao L., Cai Y., Luo R., Chen H., Xiao S. Porcine Reproductive and Respiratory Syndrome Virus Induces IL-1 β Production Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages. Mediators Inflamm. 2014:1–14. doi: 10.1155/2014/403515. 2014. - DOI - PMC - PubMed

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[1] Ahmad A., Sharif-Askari E., Fawaz L., Menezes J. Innate Immune Response of the Human Host to Exposure with Herpes Simplex Virus Type 1: In Vitro Control of the Virus Infection by Enhanced Natural Killer Activity via Interleukin-15 Induction. J. Virol. 2000;74:7196–7203. doi: 10.1128/JVI.74.16.7196-7203.2000. - DOI - PMC - PubMed

[2] Ahmad A., Sharif-Askari E., Fawaz L., Menezes J. Innate Immune Response of the Human Host to Exposure with Herpes Simplex Virus Type 1: In Vitro Control of the Virus Infection by Enhanced Natural Killer Activity via Interleukin-15 Induction. J. Virol. 2000;74:7196–7203. doi: 10.1128/JVI.74.16.7196-7203.2000. - DOI - PMC - PubMed

[3] Albina E., Carrat C., Charley B. Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. J. Interf. cytokine Res. 1998;18:485–490. doi: 10.1089/jir.1998.18.485. - DOI - PubMed

[4] Albina E., Carrat C., Charley B. Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. J. Interf. cytokine Res. 1998;18:485–490. doi: 10.1089/jir.1998.18.485. - DOI - PubMed

[5] Benfield D.A., Nelson E., Collins J.E., Harris L., Goyal S.M., Robison D., Christianson W.T., Morrison R.B., Gorcyca D., Chladek D. Characterization of Swine Infertility and Respiratory Syndrome (SIRS) Virus (Isolate ATCC VR-2332) J. Vet. Diagnostic Investig. 1992;4:127–133. doi: 10.1177/104063879200400202. - DOI - PubMed

[6] Benfield D.A., Nelson E., Collins J.E., Harris L., Goyal S.M., Robison D., Christianson W.T., Morrison R.B., Gorcyca D., Chladek D. Characterization of Swine Infertility and Respiratory Syndrome (SIRS) Virus (Isolate ATCC VR-2332) J. Vet. Diagnostic Investig. 1992;4:127–133. doi: 10.1177/104063879200400202. - DOI - PubMed

[7] Beura L.K., Sarkar S.N., Kwon B., Subramaniam S., Jones C., Pattnaik A.K., Osorio F.A. Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1β Modulates Host Innate Immune Response by Antagonizing IRF3 Activation. J. Virol. 2010;84:1574–1584. doi: 10.1128/JVI.01326-09. - DOI - PMC - PubMed

[8] Beura L.K., Sarkar S.N., Kwon B., Subramaniam S., Jones C., Pattnaik A.K., Osorio F.A. Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1β Modulates Host Innate Immune Response by Antagonizing IRF3 Activation. J. Virol. 2010;84:1574–1584. doi: 10.1128/JVI.01326-09. - DOI - PMC - PubMed

[9] Bi J., Song S., Fang L., Wang D., Jing H., Gao L., Cai Y., Luo R., Chen H., Xiao S. Porcine Reproductive and Respiratory Syndrome Virus Induces IL-1 β Production Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages. Mediators Inflamm. 2014:1–14. doi: 10.1155/2014/403515. 2014. - DOI - PMC - PubMed

[10] Bi J., Song S., Fang L., Wang D., Jing H., Gao L., Cai Y., Luo R., Chen H., Xiao S. Porcine Reproductive and Respiratory Syndrome Virus Induces IL-1 β Production Depending on TLR4/MyD88 Pathway and NLRP3 Inflammasome in Primary Porcine Alveolar Macrophages. Mediators Inflamm. 2014:1–14. doi: 10.1155/2014/403515. 2014. - DOI - PMC - PubMed

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Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

Affiliations

Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

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Abstract

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