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Meta-Analysis
. 2020 Jul;14(4):365-373.
doi: 10.1111/irv.12745. Epub 2020 Apr 21.

Medical masks vs N95 respirators for preventing COVID-19 in healthcare workers: A systematic review and meta-analysis of randomized trials

Jessica J Bartoszko  1 , Mohammed Abdul Malik Farooqi  2 , Waleed Alhazzani  1   3 , Mark Loeb  1   4
Affiliations
Meta-Analysis

Medical masks vs N95 respirators for preventing COVID-19 in healthcare workers: A systematic review and meta-analysis of randomized trials

Jessica J Bartoszko et al. Influenza Other Respir Viruses. 2020 Jul.

Abstract

Background: Respiratory protective devices are critical in protecting against infection in healthcare workers at high risk of novel 2019 coronavirus disease (COVID-19); however, recommendations are conflicting and epidemiological data on their relative effectiveness against COVID-19 are limited.

Purpose: To compare medical masks to N95 respirators in preventing laboratory-confirmed viral infection and respiratory illness including coronavirus specifically in healthcare workers.

Data sources: MEDLINE, Embase, and CENTRAL from January 1, 2014, to March 9, 2020. Update of published search conducted from January 1, 1990, to December 9, 2014.

Study selection: Randomized controlled trials (RCTs) comparing the protective effect of medical masks to N95 respirators in healthcare workers.

Data extraction: Reviewer pair independently screened, extracted data, and assessed risk of bias and the certainty of the evidence.

Data synthesis: Four RCTs were meta-analyzed adjusting for clustering. Compared with N95 respirators; the use of medical masks did not increase laboratory-confirmed viral (including coronaviruses) respiratory infection (OR 1.06; 95% CI 0.90-1.25; I2 = 0%; low certainty in the evidence) or clinical respiratory illness (OR 1.49; 95% CI: 0.98-2.28; I2 = 78%; very low certainty in the evidence). Only one trial evaluated coronaviruses separately and found no difference between the two groups (P = .49).

Limitations: Indirectness and imprecision of available evidence.

Conclusions: Low certainty evidence suggests that medical masks and N95 respirators offer similar protection against viral respiratory infection including coronavirus in healthcare workers during non-aerosol-generating care. Preservation of N95 respirators for high-risk, aerosol-generating procedures in this pandemic should be considered when in short supply.

Keywords: COVID-19; N95 respirators; SARS-CoV-2; coronavirus; masks; meta-analysis; systematic review.

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Figures

Figure 1
Figure 1
PRISMA study flow diagram (randomized controlled trials, RCTs)
Figure 2
Figure 2
Meta‐analyses of 4 randomized controlled trials comparing medical masks to N95 respirators in preventing A, Laboratoryconfirmed viral respiratory infection; B, Laboratory‐confirmed influenza infection; C, Influenza‐like illness; and D, Clinical respiratory illness
See this image and copyright information in PMC

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References

    1. World Health Organization . WHO declares COVID‐19 a pandemic. 2020. https://www.who.int/dg/speeches/detail/who‐director‐general‐s‐opening‐re.... Accessed March 13, 2020.
    1. Johnston LB, Conly JM. Severe acute respiratory syndrome: What have we learned two years later? Can J Infect Dis Med Microbiol. 2004; 15(6): 309‐312. - PMC - PubMed
    1. Wang D, Hu B, Hu C et al Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus‐infected pneumonia in wuhan, China. JAMA. 2020;323(11):1061‐1069. - PMC - PubMed
    1. The Novel Coronavirus Pneumonia Emergency Response Epidemiology Team . The Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID‐19) — China, 2020[J]. China CDC Weekly. 2020;2(8):113‐122. - PMC - PubMed
    1. Centers for Disease Control and Prevention (CDC) . COVID‐19 transmission. 2020. https://www.cdc.gov/coronavirus/2019‐ncov/prepare/transmission.html. Accessed March 15, 2020.

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