Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar;168(5):677-680.
doi: 10.1007/s10517-020-04779-9. Epub 2020 Apr 4.

Beta-Catenin in Non-Small Cells Lung Cancer and Its Association with Proteasomes

E S Kolegova  1 , E E Shashova  2 , D N Kostromitskii  3 , A Yu Dobrodeev  2 , I V Kondakova  2
Affiliations

Beta-Catenin in Non-Small Cells Lung Cancer and Its Association with Proteasomes

E S Kolegova et al. Bull Exp Biol Med. 2020 Mar.

Abstract

We analyzed the content of β-catenin fractions and activity and content of proteasomes in the tissues of patients with non-small cells lung cancer. The content of β-catenin fractions was elevated and proteasome-dependent proteolysis in the tumor tissue was enhanced in comparison with the corresponding unchanged lung tissue. A negative regression relationship of caspase-like activity of proteasomes and a positive correlation between the content of proteasomes and both fractions of β-catenin were found. We hypothesize that proteasomes are involved in the degradation of β-catenin due to caspase-like activity.

Keywords: non-small cell lung cancer (NSCLC); proteasomes; proteolysis; β-catenin.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

LinkOut - more resources