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Review
. 2020 Jun;18(6):551-562.
doi: 10.1080/14787210.2020.1750368. Epub 2020 Apr 13.

Multidrug-resistant Candida auris: an epidemiological review

Arunaloke Chakrabarti  1 , Shreya Singh  1
Affiliations
Review

Multidrug-resistant Candida auris: an epidemiological review

Arunaloke Chakrabarti et al. Expert Rev Anti Infect Ther. 2020 Jun.

Abstract

Introduction: Since the emergence of Candida auris infection in 2009, the disease has been reported from multiple countries within a decade. The infection is classified under urgent threat, as it is multi-drug resistant, causes high mortality, spreads easily in hospital setting and is difficult to identify. Whole-genome sequencing has provided insights into this organisms biology and epidemiology. A comprehensive review of those issues would help the clinicians and scientists facing C. auris infection.Areas covered: We reviewed the epidemiological trends of C. auris infection, including the genomic epidemiology based on an electronic search using Pubmed and Google scholar. We also discuss the biology, virulence attributes of this pathogen, its clinical presentations and associated risk factors. The mechanisms of antifungal resistance known so far are also described in addition to factors involved in the nosocomial transmission, environmental survival and ecology of C. auris.Expert opinion: Despite the attention of multiple researchers evaluating every aspect of this organism and its epidemiology, there are several gaps in tracing its origin and understanding the dynamics of nosocomial transmission and global spread. Multidisciplinary, coordinated studies are required to understand the biology, ecology, method of survival and spread of the organism in healthcare setup.

Keywords: Candida auris; clades; environmental survival; epidemiology; invasive candidiasis; nosocomial; resistance; transmission; virulence.

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