Do children need a longer time to shed SARS-CoV-2 in stool than adults?

doi:10.1016/j.jmii.2020.03.010

. 2020 Jun;53(3):373-376.

doi: 10.1016/j.jmii.2020.03.010. Epub 2020 Mar 19.

Do children need a longer time to shed SARS-CoV-2 in stool than adults?

Xiang Ma¹, Liang Su², Yunkui Zhang³, Xiuzhen Zhang⁴, Zhongtao Gai⁵, Zhongfa Zhang⁶

Affiliations

¹ Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, Shandong, 250022, China. Electronic address: maxiang0176@163.com.
² Department of Infectious Diseases, Jinan Infectious Diseases Hospital, Jinan, Shandong, 250021, China. Electronic address: su_li@126.com.
³ Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, Shandong, 250022, China. Electronic address: zhyk6606@aliyun.com.
⁴ Department of Infectious Diseases, Jinan Infectious Diseases Hospital, Jinan, Shandong, 250021, China. Electronic address: yyt19741009@126.com.
⁵ Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, Shandong, 250022, China; Jinan Institute of Pediatrics, Qilu Children's Hospital of Shandong University, Jinan, Shandong, 250022, China. Electronic address: gaizhongtao@sina.com.
⁶ Department of Infectious Diseases, Jinan Infectious Diseases Hospital, Jinan, Shandong, 250021, China. Electronic address: zzf235@163.com.

PMID: 32224116
PMCID: PMC7138153
DOI: 10.1016/j.jmii.2020.03.010

Do children need a longer time to shed SARS-CoV-2 in stool than adults?

Xiang Ma et al. J Microbiol Immunol Infect. 2020 Jun.

. 2020 Jun;53(3):373-376.

doi: 10.1016/j.jmii.2020.03.010. Epub 2020 Mar 19.

Authors

Xiang Ma¹, Liang Su², Yunkui Zhang³, Xiuzhen Zhang⁴, Zhongtao Gai⁵, Zhongfa Zhang⁶

Affiliations

¹ Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, Shandong, 250022, China. Electronic address: maxiang0176@163.com.
² Department of Infectious Diseases, Jinan Infectious Diseases Hospital, Jinan, Shandong, 250021, China. Electronic address: su_li@126.com.
³ Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, Shandong, 250022, China. Electronic address: zhyk6606@aliyun.com.
⁴ Department of Infectious Diseases, Jinan Infectious Diseases Hospital, Jinan, Shandong, 250021, China. Electronic address: yyt19741009@126.com.
⁵ Department of Respiratory, Qilu Children's Hospital of Shandong University, Jinan, Shandong, 250022, China; Jinan Institute of Pediatrics, Qilu Children's Hospital of Shandong University, Jinan, Shandong, 250022, China. Electronic address: gaizhongtao@sina.com.
⁶ Department of Infectious Diseases, Jinan Infectious Diseases Hospital, Jinan, Shandong, 250021, China. Electronic address: zzf235@163.com.

PMID: 32224116
PMCID: PMC7138153
DOI: 10.1016/j.jmii.2020.03.010

Abstract

SARS-CoV-2 can be shed in the stool of patients in the recovery phase. Children show a longer shedding time than adults. We analyzed the possible causes of this finding and recommend that a negative stool sample be included in a patient's discharge criteria.

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Conflict of interest statement

Declaration of Competing Interest All authors report no conflicts of interest relevant to this article.

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References

1. National Health Commission of People’s Republic of China Diagnosis and treatment of new coronavirus pneumonitis. http://117.128.6.32/cache/www.nhc.gov.cn/jkj/s3577/202002/a5d6f7b8c48c45... 5th ed., Chinese, available from:
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1. Duan S.M., Zhao X.S., Wen R.F., Huang J.J., Pi G.H., Zhang S.X. Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation. Biomed Environ Sci. 2003;16(3):246–255. PMID: 14631830. - PubMed
1. Xu K., Cai H., Shen Y., Ni Q., Chen Y., Hu S. Management of Corona virus disease-19 (COVID-19): the Zhejiang experience. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020;49(1) 0. PMID: 32096367. - PMC - PubMed
1. Xu D., Zhang Z., Jin L., Chu F., Mao Y., Wang H. Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase. Eur J Clin Microbiol Infect Dis. 2005;24(3):165–171. doi: 10.1007/s10096-005-1299-5. PMID: 15789222. - DOI - PMC - PubMed

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[1] National Health Commission of People’s Republic of China Diagnosis and treatment of new coronavirus pneumonitis. http://117.128.6.32/cache/www.nhc.gov.cn/jkj/s3577/202002/a5d6f7b8c48c45... 5th ed., Chinese, available from:

[2] National Health Commission of People’s Republic of China Diagnosis and treatment of new coronavirus pneumonitis. http://117.128.6.32/cache/www.nhc.gov.cn/jkj/s3577/202002/a5d6f7b8c48c45... 5th ed., Chinese, available from:

[3] Gralinski L.E., Menachery V.D. Return of the coronavirus: 2019-nCoV. Viruses. 2020;12(2):E135. doi: 10.3390/v12020135. PMID: 31991541. - DOI - PMC - PubMed

[4] Gralinski L.E., Menachery V.D. Return of the coronavirus: 2019-nCoV. Viruses. 2020;12(2):E135. doi: 10.3390/v12020135. PMID: 31991541. - DOI - PMC - PubMed

[5] Duan S.M., Zhao X.S., Wen R.F., Huang J.J., Pi G.H., Zhang S.X. Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation. Biomed Environ Sci. 2003;16(3):246–255. PMID: 14631830. - PubMed

[6] Duan S.M., Zhao X.S., Wen R.F., Huang J.J., Pi G.H., Zhang S.X. Stability of SARS coronavirus in human specimens and environment and its sensitivity to heating and UV irradiation. Biomed Environ Sci. 2003;16(3):246–255. PMID: 14631830. - PubMed

[7] Xu K., Cai H., Shen Y., Ni Q., Chen Y., Hu S. Management of Corona virus disease-19 (COVID-19): the Zhejiang experience. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020;49(1) 0. PMID: 32096367. - PMC - PubMed

[8] Xu K., Cai H., Shen Y., Ni Q., Chen Y., Hu S. Management of Corona virus disease-19 (COVID-19): the Zhejiang experience. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2020;49(1) 0. PMID: 32096367. - PMC - PubMed

[9] Xu D., Zhang Z., Jin L., Chu F., Mao Y., Wang H. Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase. Eur J Clin Microbiol Infect Dis. 2005;24(3):165–171. doi: 10.1007/s10096-005-1299-5. PMID: 15789222. - DOI - PMC - PubMed

[10] Xu D., Zhang Z., Jin L., Chu F., Mao Y., Wang H. Persistent shedding of viable SARS-CoV in urine and stool of SARS patients during the convalescent phase. Eur J Clin Microbiol Infect Dis. 2005;24(3):165–171. doi: 10.1007/s10096-005-1299-5. PMID: 15789222. - DOI - PMC - PubMed

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Do children need a longer time to shed SARS-CoV-2 in stool than adults?

Affiliations

Do children need a longer time to shed SARS-CoV-2 in stool than adults?

Authors

Affiliations

Abstract

Conflict of interest statement

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