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. 2020 Dec;46(12):1500-1505.
doi: 10.1097/DSS.0000000000002378.

A Review of 3-Dimensional Skin Bioprinting Techniques: Applications, Approaches, and Trends

Stephanie Ishack  1 , Shari R Lipner
Affiliations

A Review of 3-Dimensional Skin Bioprinting Techniques: Applications, Approaches, and Trends

Stephanie Ishack et al. Dermatol Surg. 2020 Dec.

Abstract

Background: Tissue engineering is used to fabricate 3-dimensional (3D) artificial scaffolds to create a microenvironment that mimics human tissue. Bioprinting uses biomaterials, cells, and/or bioink to fabricate prospective scaffolds to mirror the structural, compositional, and functional aspects of the skin. Various bioprinting methods (inkjet-based bioprinting, pressure-assisted bioprinting, and laser-assisted bioprinting) have been used for regenerative wound repair and have been characterized based on biocompatibility, cellular microenvironment, cell proliferation, vitality, and morphology.

Objective: This article reviews the basic principles of 3D printing, current 3D skin bioprinting applications and approaches, and future directions for regenerative medical skin constructs.

Methods: A comprehensive literature review was conducted using PubMed with keywords "three-dimensional printing," "dermatologic surgery," "bioprinting," "reconstructive surgical procedures," "wound healing," "skin grafts," "skin scaffolds," "tissue reconstruction," and "tissue engineering."

Results: A summary of the different applications and 3-dimensional skin bioprinting techniques is presented. In addition, synthetic, natural, and combination polymers are reviewed. Advantages, disadvantages, indications, and approaches are discussed in depth.

Conclusion: Skin grafting is a dynamic technique of dermal reconstruction that can be successful with comprehensive knowledge of skin bioprinting methods.

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Comment in

  • Commentary on 3-Dimensional Printing.
    Merritt J, Konda S. Merritt J, et al. Dermatol Surg. 2020 Dec;46(12):1506-1507. doi: 10.1097/DSS.0000000000002348. Dermatol Surg. 2020. PMID: 33252458 No abstract available.

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