Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
- PMID: 32194981
- PMCID: PMC7078228
- DOI: 10.1038/s41421-020-0156-0
Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro
Keywords: Autophagy; Transcription.
Conflict of interest statement
Conflict of interestThe authors declare that they have no conflict of interest.
Figures
Comment in
-
Chloroquine and hydroxychloroquine for COVID-19: implications for cardiac safety.Eur Heart J Cardiovasc Pharmacother. 2020 Jul 1;6(4):256-257. doi: 10.1093/ehjcvp/pvaa041. Eur Heart J Cardiovasc Pharmacother. 2020. PMID: 32347923 Free PMC article. No abstract available.
Similar articles
-
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).Clin Infect Dis. 2020 Jul 28;71(15):732-739. doi: 10.1093/cid/ciaa237. Clin Infect Dis. 2020. PMID: 32150618 Free PMC article.
-
Insights into antiviral mechanisms of remdesivir, lopinavir/ritonavir and chloroquine/hydroxychloroquine affecting the new SARS-CoV-2.Biomed Pharmacother. 2020 Nov;131:110668. doi: 10.1016/j.biopha.2020.110668. Epub 2020 Aug 24. Biomed Pharmacother. 2020. PMID: 32861965 Free PMC article. Review.
-
Toxicity of chloroquine and hydroxychloroquine following therapeutic use or overdose.Clin Toxicol (Phila). 2021 Jan;59(1):12-23. doi: 10.1080/15563650.2020.1817479. Epub 2020 Sep 22. Clin Toxicol (Phila). 2021. PMID: 32960100 Review.
-
Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection.Int J Antimicrob Agents. 2020 May;55(5):105960. doi: 10.1016/j.ijantimicag.2020.105960. Epub 2020 Apr 3. Int J Antimicrob Agents. 2020. PMID: 32251731 Free PMC article.
-
In silico study of azithromycin, chloroquine and hydroxychloroquine and their potential mechanisms of action against SARS-CoV-2 infection.Int J Antimicrob Agents. 2020 Sep;56(3):106119. doi: 10.1016/j.ijantimicag.2020.106119. Epub 2020 Jul 30. Int J Antimicrob Agents. 2020. PMID: 32738306 Free PMC article.
Cited by
-
Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial.PLoS Med. 2024 Sep 12;21(9):e1004428. doi: 10.1371/journal.pmed.1004428. eCollection 2024 Sep. PLoS Med. 2024. PMID: 39264960 Free PMC article. Clinical Trial.
-
SLC38A9 regulates SARS-CoV-2 viral entry.iScience. 2024 Jun 27;27(7):110387. doi: 10.1016/j.isci.2024.110387. eCollection 2024 Jul 19. iScience. 2024. PMID: 39071889 Free PMC article.
-
Preclinical and Clinical Investigations of Potential Drugs and Vaccines for COVID-19 Therapy: A Comprehensive Review With Recent Update.Clin Pathol. 2024 Jul 26;17:2632010X241263054. doi: 10.1177/2632010X241263054. eCollection 2024 Jan-Dec. Clin Pathol. 2024. PMID: 39070952 Free PMC article. Review.
-
Network pharmacology, molecular docking, and dynamics analyses to predict the antiviral activity of ginger constituents against coronavirus infection.Sci Rep. 2024 May 27;14(1):12059. doi: 10.1038/s41598-024-60721-3. Sci Rep. 2024. PMID: 38802394 Free PMC article.
-
Analysis of the Prophylactic use of Hydroxychloroquine at the Beginning of the COVID-19 Pandemic Among Physicians.Infect Dis Clin Microbiol. 2022 Dec 21;4(4):236-243. doi: 10.36519/idcm.2022.111. eCollection 2022 Dec. Infect Dis Clin Microbiol. 2022. PMID: 38633712 Free PMC article.
References
-
- Weniger H. Review of side effects and toxicity of chloroquine. Bull. World Health. 1979;79:906.
Publication types
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous