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. 2020 Feb 24:2020:5184084.
doi: 10.1155/2020/5184084. eCollection 2020.

Association of Motor and Cognitive Symptoms with Health-Related Quality of Life and Caregiver Burden in a German Cohort of Advanced Parkinson's Disease Patients

M Klietz #  1 , T Schnur #  1 , S Drexel  1 , F Lange  2 , A Tulke  1 , L Rippena  1 , L Paracka  1 , D Dressler  1 , G U Höglinger  1 , F Wegner  1
Affiliations

Association of Motor and Cognitive Symptoms with Health-Related Quality of Life and Caregiver Burden in a German Cohort of Advanced Parkinson's Disease Patients

M Klietz et al. Parkinsons Dis. .

Abstract

Parkinson's disease (PD) is a chronic progressive movement disorder with severe reduction in patients' health-related quality of life (HR-QoL). Motor and cognitive symptoms are especially linked with decreased PD patients' HR-QoL. However, the relationship of these symptoms to caregiver burden is relatively unclear. Influence of the Montreal Cognitive Assessment scale (MoCA) as a cognitive screening tool and Movement Disorders Society Unified Parkinson's disease Rating Scale MDS-UPDRS symptoms in relation to patients' HR-QoL and caregivers` burden was analyzed. PD patients (n = 124) completed MDS-UPDRS, MoCA, and the PD questionnaire 8 (PDQ-8) as a measure of quality of life. Caregivers (n = 78) were assessed by the PD caregiver burden inventory (PDCB). PDQ-8 and PDCB scores were regressed on MDS-UPDRS subscales and MoCA subscores. PDQ-8 correlated with attention (R 2 0.1282; p < 0.001) and executive (R 2 0.0882; p 0.001) MoCA subscores and all parts of the MDS-UPDRS. PDCB correlated most strongly with MDS-UPDRS part III motor symptoms (R 2 0.2070; p < 0.001) and the MoCA attention subscore (R 2 0.1815; p < 0.001). While all facets of PD symptoms assessed by the MDS-UPDRS relate to PD patients' quality of life, motor symptoms are the most relevant factor for the prediction of caregiver burden. In addition, patients' attentional symptoms seem to affect not only them, but also their caregivers. These findings show the potential of a detailed analysis of MDS-UPDRS and MoCA performance in PD patients.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

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References

    1. Heinzel S., Berg D., Binder S., et al. Do we need to rethink the epidemiology and healthcare utilization of Parkinson’s disease in Germany? Frontiers in Neurology. 2018;9:p. 500. doi: 10.3389/fneur.2018.00500. - DOI - PMC - PubMed
    1. Carod-Artal F. J., Vargas A. P., Martinez-Martin P. Determinants of quality of life in Brazilian patients with Parkinson’s disease. Movement Disorders. 2007;22(10):1408–1415. doi: 10.1002/mds.21408. - DOI - PubMed
    1. Li H., Zhang M., Chen L., et al. Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson’s disease. Movement Disorders. 2010;25(16):2740–2746. doi: 10.1002/mds.23368. - DOI - PubMed
    1. Klietz M., Tulke A., Müschen L. H., et al. Impaired quality of life and need for palliative care in a German cohort of advanced Parkinson’s disease patients. Frontiers in Neurology. 2018;9:473–478. doi: 10.3389/fneur.2018.00120. - DOI - PMC - PubMed
    1. Martinez-Martin P., Rodriguez-Blazquez C., Kurtis M. M., Chaudhuri K. R., NMSS Validation Group The impact of non-motor symptoms on health-related quality of life of patients with Parkinson’s disease. Movement Disorders. 2011;26(3):399–406. doi: 10.1002/mds.23462. - DOI - PubMed