COVID-19 and the cardiovascular system

doi:10.1038/s41569-020-0360-5

. 2020 May;17(5):259-260.

doi: 10.1038/s41569-020-0360-5.

COVID-19 and the cardiovascular system

Ying-Ying Zheng^{1

2}, Yi-Tong Ma³, Jin-Ying Zhang^{4

5}, Xiang Xie⁶

Affiliations

¹ Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China.
³ Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. myt_xj@sina.com.
⁴ Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. jyzhang@zzu.edu.cn.
⁵ Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China. jyzhang@zzu.edu.cn.
⁶ Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. xiangxie999@sina.com.

PMID: 32139904
PMCID: PMC7095524
DOI: 10.1038/s41569-020-0360-5

COVID-19 and the cardiovascular system

Ying-Ying Zheng et al. Nat Rev Cardiol. 2020 May.

. 2020 May;17(5):259-260.

doi: 10.1038/s41569-020-0360-5.

Authors

Ying-Ying Zheng^{1

2}, Yi-Tong Ma³, Jin-Ying Zhang^{4

5}, Xiang Xie⁶

Affiliations

¹ Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China.
³ Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. myt_xj@sina.com.
⁴ Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. jyzhang@zzu.edu.cn.
⁵ Key Laboratory of Cardiac Injury and Repair of Henan Province, Zhengzhou, China. jyzhang@zzu.edu.cn.
⁶ Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. xiangxie999@sina.com.

PMID: 32139904
PMCID: PMC7095524
DOI: 10.1038/s41569-020-0360-5

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects host cells through ACE2 receptors, leading to coronavirus disease (COVID-19)-related pneumonia, while also causing acute myocardial injury and chronic damage to the cardiovascular system. Therefore, particular attention should be given to cardiovascular protection during treatment for COVID-19.

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Conflict of interest statement

The authors declare no competing interests.

Comment in

Interaction between RAAS inhibitors and ACE2 in the context of COVID-19.
Mourad JJ, Levy BI. Mourad JJ, et al. Nat Rev Cardiol. 2020 May;17(5):313. doi: 10.1038/s41569-020-0368-x. Nat Rev Cardiol. 2020. PMID: 32231328 Free PMC article. No abstract available.
Mechanisms by which angiotensin-receptor blockers increase ACE2 levels.
Ferrario CM, Ahmad S, Groban L. Ferrario CM, et al. Nat Rev Cardiol. 2020 Jun;17(6):378. doi: 10.1038/s41569-020-0387-7. Nat Rev Cardiol. 2020. PMID: 32332868 Free PMC article. No abstract available.

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References

1. Wang D, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020 doi: 10.1001/jama.2020.1585. - DOI - PMC - PubMed
1. Zhou P, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed
1. Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed
1. Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol. Sci. 2004;25:291–294. doi: 10.1016/j.tips.2004.04.001. - DOI - PMC - PubMed
1. Alhogbani T. Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus. Ann. Saudi Med. 2016;36:78–80. doi: 10.5144/0256-4947.2016.78. - DOI - PMC - PubMed

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[1] Wang D, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020 doi: 10.1001/jama.2020.1585. - DOI - PMC - PubMed

[2] Wang D, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020 doi: 10.1001/jama.2020.1585. - DOI - PMC - PubMed

[3] Zhou P, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed

[4] Zhou P, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 doi: 10.1038/s41586-020-2012-7. - DOI - PMC - PubMed

[5] Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed

[6] Huang C, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. doi: 10.1016/S0140-6736(20)30183-5. - DOI - PMC - PubMed

[7] Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol. Sci. 2004;25:291–294. doi: 10.1016/j.tips.2004.04.001. - DOI - PMC - PubMed

[8] Turner AJ, Hiscox JA, Hooper NM. ACE2: from vasopeptidase to SARS virus receptor. Trends Pharmacol. Sci. 2004;25:291–294. doi: 10.1016/j.tips.2004.04.001. - DOI - PMC - PubMed

[9] Alhogbani T. Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus. Ann. Saudi Med. 2016;36:78–80. doi: 10.5144/0256-4947.2016.78. - DOI - PMC - PubMed

[10] Alhogbani T. Acute myocarditis associated with novel Middle East respiratory syndrome coronavirus. Ann. Saudi Med. 2016;36:78–80. doi: 10.5144/0256-4947.2016.78. - DOI - PMC - PubMed

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COVID-19 and the cardiovascular system

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COVID-19 and the cardiovascular system

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