Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Feb 7:11:19.
doi: 10.3389/fphar.2020.00019. eCollection 2020.

The Application of DVDMS as a Sensitizing Agent for Sono-/Photo-Therapy

Bingjie Mai  1 , Xiaobing Wang  1 , Quanhong Liu  1 , Kun Zhang  1 , Pan Wang  1
Affiliations
Review

The Application of DVDMS as a Sensitizing Agent for Sono-/Photo-Therapy

Bingjie Mai et al. Front Pharmacol. .

Abstract

Both photodynamic therapy (PDT) and sonodynamic therapy (SDT) are fast growing activated therapies by using light or ultrasound to initiate catalytic reaction of sensitizing agents, showing great potentials in clinics because of high safety and noninvasiveness. Sensitizers are critical components in PDT and SDT. Sinoporphyrin sodium (DVDMS) is an effective constituent derived from Photofrin that has been approved by FDA. This review is based on previous articles that explore the applications of DVDMS mediated photodynamic/sonodynamic cancer therapy and antimicrobial chemotherapy. Researchers utilize different cell lines, distinct treatment protocols to explore the enhanced therapeutic response of neoplastic lesion. Moreover, by designing a series of nanoparticles for loading DVDMS to improve the cellular uptake and antitumor efficacy of PDT/SDT, which integrates diagnostics into therapeutics for precision medical applications. During the sono-/photo-activated process, the balance between oxidation and antioxidation, numerous signal transduction and cell death pathways are also involved. In addition, DVDMS mediated photodynamic antimicrobial chemotherapy (PACT) can effectively suppress bacteria and multidrug resistant bacteria proliferation, promote the healing of wounds in burn infection. In brief, these efficient preclinical studies indicate a good promise for DVDMS application in the activated sono-/photo-therapy.

Keywords: nanomaterials; photodynamic antimicrobial therapy; photodynamic therapy; sinoporphyrin sodium; sonodynamic therapy.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Diagram of ROS generation for photodynamically killing cancer cells and pathogenic microorganisms.
Figure 2
Figure 2
The possible mechanisms of DVDMS-SDT.
Figure 3
Figure 3
Different DVDMS nanoparticles of photo-/sono-therapy and image-guided cancer treatment. Reprinted with permission of ref. (Yan et al., 2014), (Huang et al., 2017), Royal Society Of Chemistry. (Liu et al., 2018), WILEY.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. AB O., HS F. (2013). Dye aensitizers for photodynamic therapy. Materials 6 (3), 817–840. 10.3390/ma6030817 - DOI - PMC - PubMed
    1. Allison R. R., Moghissi K. (2013). Photodynamic therapy (PDT): PDT mechanisms. Clin. Endoscopy 46 (1), 24–29. 10.5946/ce.2013.46.1.24 - DOI - PMC - PubMed
    1. Allison B. A., Waterfield E., Richter A. M., Levy J. G. (2010). The effects of plasma lipoproteins on in vitrotumor cell killing and in vivo tumor photosensitization with benzoporphyrin derivative. Photochem. Photobiol. 54 (5), 709–715. 10.1111/j.1751-1097.1991.tb02079.x - DOI - PubMed
    1. Cairns R. A., Harris I. S., Mak T. W. (2011). Regulation of cancer cell metabolism. Nat. Rev. Cancer 11 (2), 85–95. 10.1038/nrc2981 - DOI - PubMed
    1. Chu C., Lin H., Liu H., Wang X., Wang J., Zhang P., et al. (2017). Tumor microenvironment-triggered supramolecular system as an insitu nanotheranostic generator for cancer phototherapy. Adv. Mater. 29 (23), 1605928. 10.1002/adma.201605928 - DOI - PMC - PubMed