Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2020 Apr;80(4):388-393.
doi: 10.1016/j.jinf.2020.02.016. Epub 2020 Feb 26.

Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China

Wenjie Yang  1 , Qiqi Cao  1 , Le Qin  1 , Xiaoyang Wang  2 , Zenghui Cheng  1 , Ashan Pan  3 , Jianyi Dai  4 , Qingfeng Sun  5 , Fengquan Zhao  4 , Jieming Qu  6 , Fuhua Yan  7
Affiliations
Multicenter Study

Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19):A multi-center study in Wenzhou city, Zhejiang, China

Wenjie Yang et al. J Infect. 2020 Apr.

Abstract

Background: Little is known about COVID-19 outside Hubei. The aim of this paper was to describe the clinical characteristics and imaging manifestations of hospitalized patients with confirmed COVID-19 infection in Wenzhou, Zhejiang, China.

Methods: In this retrospective cohort study, 149 RT-PCR confirmed positive patients were consecutively enrolled from January 17th to February 10th, 2020 in three tertiary hospitals of Wenzhou. Outcomes were followed up until Feb 15th, 2020.

Findings: A total of 85 patients had Hubei travel/residence history, while another 49 had contact with people from Hubei and 15 had no traceable exposure history to Hubei. Fever, cough and expectoration were the most common symptoms, 14 patients had decreased oxygen saturation, 33 had leukopenia, 53 had lymphopenia, and 82 had elevated C-reactive protein. On chest computed tomography (CT), lung segments 6 and 10 were mostly involved. A total of 287 segments presented ground glass opacity, 637 presented mixed opacity and 170 presented consolidation. Lesions were more localized in the peripheral lung with a patchy form. No significant difference was found between patients with or without Hubei exposure history. Seventeen patients had normal CT on admission of these, 12 had negative findings even10 days later.

Interpretation: Most patients presented with a mild infection in our study. The imaging pattern of multifocal peripheral ground glass or mixed opacity with predominance in the lower lung is highly suspicious of COVID-19 in the first week of disease onset. Nevetheless, some patients can present with a normal chest finding despite testing positive for COVID-19.

Funding: We did not receive any fundings.

Keywords: COVID-19; CT; Infection; Lung; Outside Hubei.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors of this study declare that they each have no conflict of interest.

Figures

Fig. 1
Fig. 1
Chest CT of a male patient, 37 years old. This individual came back from Wuhan to Wenzhou on January 19th. He presented with cough and expectoration. He underwent a chest CT examination on January 24th, which showed subtle peripheral ground glass opacity in the middle lobe, and right inferior lobe. He was hospitalized on the same day. The RT-PCR test was done and was found to be positive. The CT images of January 27th and February 2nd showed a significant increase of lesion number and density, especially in the both lower lobes. Two RT-PCR tests were performed on February 4th and 7th and both results were negative. The CT images of February 7th showed a decrease in density of the pulmonary lesions. On the CT examination of February 15th, the lesions were absorbed and the patient was discharged. During the hospitalization, the patient had arbidol as antiviral treatment and nasal spray of interferon, no oxygen therapy was performed since the oxygen saturation of the patient remained normal. The patient had no fever during the entire disease course.
See this image and copyright information in PMC

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Zhu N., Zhang D., Wang W. A novel coronavirus from patients with pneumonia in China, 2019 [published online ahead of print, 2020 Jan 24] N Engl J Med. 2020 doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed
    1. Huang C., Wang Y., Li X. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published online ahead of print, 2020 Jan 24] Lancet. 2020 S0140-6736(20)30183-5. - PMC - PubMed
    1. Li Q., Guan X., Wu P. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia [published online ahead of print, 2020 Jan 29] N Engl J Med. 2020 doi: 10.1056/NEJMoa2001316. - DOI - PMC - PubMed
    1. N. Chen, M. Zhou, X. Dong et al., Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. [published online ahead of print, 2020 Jan 29]. Lancet. - PMC - PubMed
    1. Chan J.F., Yuan S., Kok K.H. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster [published online ahead of print, 2020 Jan 24] Lancet. 2020 S0140-6736(20)30154-9. - PMC - PubMed

Publication types

MeSH terms