Consistent Detection of 2019 Novel Coronavirus in Saliva

doi:10.1093/cid/ciaa149

. 2020 Jul 28;71(15):841-843.

doi: 10.1093/cid/ciaa149.

Consistent Detection of 2019 Novel Coronavirus in Saliva

Kelvin Kai-Wang To^{1

2

3}, Owen Tak-Yin Tsang⁴, Cyril Chik-Yan Yip^{1

2}, Kwok-Hung Chan¹, Tak-Chiu Wu⁵, Jacky Man-Chun Chan⁴, Wai-Shing Leung⁴, Thomas Shiu-Hong Chik⁴, Chris Yau-Chung Choi⁴, Darshana H Kandamby⁶, David Christopher Lung⁷, Anthony Raymond Tam⁸, Rosana Wing-Shan Poon^{1

2}, Agnes Yim-Fong Fung¹, Ivan Fan-Ngai Hung⁸, Vincent Chi-Chung Cheng^{1

2}, Jasper Fuk-Woo Chan^{1

2

3}, Kwok-Yung Yuen^{1

2

3}

Affiliations

¹ State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
² Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
³ Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
⁴ Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong Special Administrative Region, China.
⁵ Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China.
⁶ Intensive Care Unit, Princess Margaret Hospital, Hong Kong Special Administrative Region, China.
⁷ Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China.
⁸ Department of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China.

PMID: 32047895
PMCID: PMC7108139
DOI: 10.1093/cid/ciaa149

Consistent Detection of 2019 Novel Coronavirus in Saliva

Kelvin Kai-Wang To et al. Clin Infect Dis. 2020.

. 2020 Jul 28;71(15):841-843.

doi: 10.1093/cid/ciaa149.

Authors

Affiliations

¹ State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology, Carol Yu Centre for Infection, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China.
² Department of Microbiology, Queen Mary Hospital, Hong Kong Special Administrative Region, China.
³ Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen, China.
⁴ Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong Special Administrative Region, China.
⁵ Department of Medicine, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China.
⁶ Intensive Care Unit, Princess Margaret Hospital, Hong Kong Special Administrative Region, China.
⁷ Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China.
⁸ Department of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China.

PMID: 32047895
PMCID: PMC7108139
DOI: 10.1093/cid/ciaa149

Abstract

The 2019 novel coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) of patients. Serial saliva viral load monitoring generally showed a declining trend. Live virus was detected in saliva by viral culture. Saliva is a promising noninvasive specimen for diagnosis, monitoring, and infection control in patients with 2019-nCoV infection.

Keywords: 2019 novel coronavirus; COVID-19; diagnostics; saliva; transmission; viral load.

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Figures

**Figure 1.**
Saliva viral load in patients with 2019 novel coronavirus infection. For this figure, specimens with undetected viral load were assigned a value of 10¹.

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Comment in

The probability of detection of SARS-CoV-2 in saliva.
Thompson RN, Cunniffe NJ. Thompson RN, et al. Stat Methods Med Res. 2020 Apr;29(4):1049-1050. doi: 10.1177/0962280220915049. Stat Methods Med Res. 2020. PMID: 32338180 No abstract available.

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References

1. Peiris JS, Lai ST, Poon LL, et al. ; SARS Study Group Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003; 361:1319–25. - PMC - PubMed
1. Chan JF, Yuan S, Kok KH, et al. . A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020. pii: S0140-6736(20)30154-9. - PMC - PubMed
1. Huang C, Wang Y, Li X, et al. . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020. pii: S0140-6736(20)30183-5. - PMC - PubMed
1. Chan JF, Kok KH, Zhu Z, et al. . Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect 2020; 9:221–36. - PMC - PubMed
1. To KK, Lu L, Yip CC, et al. . Additional molecular testing of saliva specimens improves the detection of respiratory viruses. Emerg Microbes Infect 2017; 6:e49. - PMC - PubMed

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[1] Peiris JS, Lai ST, Poon LL, et al. ; SARS Study Group Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003; 361:1319–25. - PMC - PubMed

[2] Peiris JS, Lai ST, Poon LL, et al. ; SARS Study Group Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003; 361:1319–25. - PMC - PubMed

[3] Chan JF, Yuan S, Kok KH, et al. . A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020. pii: S0140-6736(20)30154-9. - PMC - PubMed

[4] Chan JF, Yuan S, Kok KH, et al. . A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020. pii: S0140-6736(20)30154-9. - PMC - PubMed

[5] Huang C, Wang Y, Li X, et al. . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020. pii: S0140-6736(20)30183-5. - PMC - PubMed

[6] Huang C, Wang Y, Li X, et al. . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020. pii: S0140-6736(20)30183-5. - PMC - PubMed

[7] Chan JF, Kok KH, Zhu Z, et al. . Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect 2020; 9:221–36. - PMC - PubMed

[8] Chan JF, Kok KH, Zhu Z, et al. . Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerg Microbes Infect 2020; 9:221–36. - PMC - PubMed

[9] To KK, Lu L, Yip CC, et al. . Additional molecular testing of saliva specimens improves the detection of respiratory viruses. Emerg Microbes Infect 2017; 6:e49. - PMC - PubMed

[10] To KK, Lu L, Yip CC, et al. . Additional molecular testing of saliva specimens improves the detection of respiratory viruses. Emerg Microbes Infect 2017; 6:e49. - PMC - PubMed

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Consistent Detection of 2019 Novel Coronavirus in Saliva

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Consistent Detection of 2019 Novel Coronavirus in Saliva

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