Decoding the Biology of Exosomes in Metastasis

doi:10.1016/j.trecan.2019.11.007

Review

. 2020 Jan;6(1):20-30.

doi: 10.1016/j.trecan.2019.11.007. Epub 2019 Dec 10.

Decoding the Biology of Exosomes in Metastasis

Bárbara Adem¹, Patricia F Vieira², Sonia A Melo³

Affiliations

¹ i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Institute of Molecular Pathology and Immunology of University of Porto, IPATIMUP, Porto, Portugal; Instituto de Ciências Biomédicas de Abel Salazar, University of Porto, Porto, Portugal.
² i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Institute of Molecular Pathology and Immunology of University of Porto, IPATIMUP, Porto, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
³ i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Institute of Molecular Pathology and Immunology of University of Porto, IPATIMUP, Porto, Portugal; Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address: smelo@ipatimup.pt.

PMID: 31952777
DOI: 10.1016/j.trecan.2019.11.007

Review

Decoding the Biology of Exosomes in Metastasis

Bárbara Adem et al. Trends Cancer. 2020 Jan.

. 2020 Jan;6(1):20-30.

doi: 10.1016/j.trecan.2019.11.007. Epub 2019 Dec 10.

Authors

Bárbara Adem¹, Patricia F Vieira², Sonia A Melo³

Affiliations

¹ i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Institute of Molecular Pathology and Immunology of University of Porto, IPATIMUP, Porto, Portugal; Instituto de Ciências Biomédicas de Abel Salazar, University of Porto, Porto, Portugal.
² i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Institute of Molecular Pathology and Immunology of University of Porto, IPATIMUP, Porto, Portugal; Faculty of Medicine, University of Coimbra, Coimbra, Portugal.
³ i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal; Institute of Molecular Pathology and Immunology of University of Porto, IPATIMUP, Porto, Portugal; Department of Pathology, Faculty of Medicine, University of Porto, Porto, Portugal. Electronic address: smelo@ipatimup.pt.

PMID: 31952777
DOI: 10.1016/j.trecan.2019.11.007

Abstract

Metastasis is the leading cause of cancer mortality. Cancer cells must adapt to colonize and thrive at the metastatic site. The modulation of the receptive organ microenvironment is a key event in the adaptation process and is partially accomplished at a distance by the primary tumor. Exosomes, a subclass of extracellular vesicles (EVs), are distal mediators of communication that carry genetic and molecular information to neighboring and distant cells. Cancer exosomes have been involved in restructuring metastatic sites to support cancer cell colonization. In this article, we discuss the role of exosomes in the metastatic process.

Keywords: communication; exosomes; metastasis; microenvironment; reprogramming.

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Decoding the Biology of Exosomes in Metastasis

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Decoding the Biology of Exosomes in Metastasis

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