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. 2020 Jan 10:13:1.
doi: 10.1186/s13044-020-0075-z. eCollection 2020.

Cross-sectional and prospective study on anti-Müllerian hormone changes in a cohort of pre-menopausal women with a history of differentiated thyroid cancer

Miranda Mittica  1 , Andrea Dotto  1 , Martina Comina  1 , Marsida Teliti  1 , Eleonora Monti  1   2 , Massimo Giusti  1   2
Affiliations

Cross-sectional and prospective study on anti-Müllerian hormone changes in a cohort of pre-menopausal women with a history of differentiated thyroid cancer

Miranda Mittica et al. Thyroid Res. .

Abstract

Background: Anti-Müllerian hormone (AMH) decreases acutely after post-surgical radioactive iodine (RAI) ablation in females with differentiated thyroid cancer (DTC).

Aim: We performed a cross-sectional and prospective study on AMH levels in pre-menopausal females with a history of DTC.

Methods: Fifty-nine females after surgery and RAI (group 1) and 30 females after surgery alone (group 2) were studied. The control group consisted of 141 healthy women (group 3). The prospective study was performed in 43 and 14 females from groups 1 and 2, respectively.

Results: On first evaluation, AMH levels were similar in groups 1 and 2, but lower than in group 3. In all groups, AMH was negatively related with chronological age and FSH levels. When subjects were stratified according to age, AMH levels were not different between groups. When AMH was evaluated up to 2 years after the baseline evaluation, no changes emerged in either group of women with DTC. In the prospective study, the incidence of abnormal menstrual cycles and the onset of menopause were observed in similar percentages of women with a history of RAI-treated DTC and of those treated with surgery alone.

Conclusions: AMH can be considered a reliable index of ovarian reserve in women with DTC. Chronological age is the main factor influencing AMH levels in both DTC patients and controls. After age-related stratification, AMH levels are similar in women with DTC treated with RAI and those treated with surgery alone.

Keywords: AMH; Pre-menopausal women; Radioiodine; Thyroid cancer.

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Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Correlations between AMH and chronological age (top) or FSH levels (bottom) in the three groups of pre-menopausal females studied. For significance, see also Table 3
Fig. 2
Fig. 2
Mean (± SD) AMH levels observed in the three groups of pre-menopausal females stratified in quintiles according to chronological age. The number at the top of each column indicates the number of subjects in each quintile
Fig. 3
Fig. 3
Mean (± SD) AMH levels observed in group 1 and group 2 from baseline to 3rd evaluation. The number at the top of each column indicates the number of subjects at each examination
See this image and copyright information in PMC

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