Rapamycin for the aging skin

doi:10.18632/aging.102664

. 2019 Dec 27;11(24):12822-12826.

doi: 10.18632/aging.102664. Epub 2019 Dec 27.

Rapamycin for the aging skin

Mikhail V Blagosklonny¹

Affiliations

PMID: 31895693
PMCID: PMC6949048
DOI: 10.18632/aging.102664

Rapamycin for the aging skin

Mikhail V Blagosklonny. Aging (Albany NY). 2019.

. 2019 Dec 27;11(24):12822-12826.

doi: 10.18632/aging.102664. Epub 2019 Dec 27.

Author

Mikhail V Blagosklonny¹

Affiliation

¹ Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.

PMID: 31895693
PMCID: PMC6949048
DOI: 10.18632/aging.102664

No abstract available

Keywords: anti-aging; cosmetics; cream; mTOR; patents; rapamycin; topical.

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Conflict of interest statement

Conflict of Interests: The author declares no conflicts of interest.

Comment in

Commentary: rapamycin for the aging skin.
Sell C. Sell C. Geroscience. 2020 Apr;42(2):813-815. doi: 10.1007/s11357-020-00184-2. Epub 2020 Mar 29. Geroscience. 2020. PMID: 32227278 Free PMC article.

Cited by

Commentary: rapamycin for the aging skin.
Sell C. Sell C. Geroscience. 2020 Apr;42(2):813-815. doi: 10.1007/s11357-020-00184-2. Epub 2020 Mar 29. Geroscience. 2020. PMID: 32227278 Free PMC article.
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The Effects of Nutrient Signaling Regulators in Combination with Phytocannabinoids on the Senescence-Associated Phenotype in Human Dermal Fibroblasts.
Gerasymchuk M, Robinson GI, Kovalchuk O, Kovalchuk I. Gerasymchuk M, et al. Int J Mol Sci. 2022 Aug 8;23(15):8804. doi: 10.3390/ijms23158804. Int J Mol Sci. 2022. PMID: 35955938 Free PMC article.
Intestinal stem cell aging at single-cell resolution: Transcriptional perturbations alter cell developmental trajectory reversed by gerotherapeutics.
Choi J, Houston M, Wang R, Ye K, Li W, Zhang X, Huffman DM, Augenlicht LH. Choi J, et al. Aging Cell. 2023 May;22(5):e13802. doi: 10.1111/acel.13802. Epub 2023 Mar 2. Aging Cell. 2023. PMID: 36864750 Free PMC article.

References

1. Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5:2087–102. 10.4161/cc.5.18.3288 - DOI - PubMed
1. Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7:3355–61. 10.4161/cc.7.21.6919 - DOI - PubMed
1. Chung CL, Lawrence I, Hoffman M, Elgindi D, Nadhan K, Potnis M, Jin A, Sershon C, Binnebose R, Lorenzini A, Sell C. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. Geroscience. 2019; 41:861–69. 10.1007/s11357-019-00113-y - DOI - PMC - PubMed
1. Meingassner JG, Stütz A. Immunosuppressive macrolides of the type FK 506: a novel class of topical agents for treatment of skin diseases? J Invest Dermatol. 1992; 98:851–55. 10.1111/1523-1747.ep12456939 - DOI - PubMed
1. Ormerod AD, Shah SA, Copeland P, Omar G, Winfield A. Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial. Br J Dermatol. 2005; 152:758–64. 10.1111/j.1365-2133.2005.06438.x - DOI - PubMed

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[1] Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5:2087–102. 10.4161/cc.5.18.3288 - DOI - PubMed

[2] Blagosklonny MV. Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle. 2006; 5:2087–102. 10.4161/cc.5.18.3288 - DOI - PubMed

[3] Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7:3355–61. 10.4161/cc.7.21.6919 - DOI - PubMed

[4] Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle. 2008; 7:3355–61. 10.4161/cc.7.21.6919 - DOI - PubMed

[5] Chung CL, Lawrence I, Hoffman M, Elgindi D, Nadhan K, Potnis M, Jin A, Sershon C, Binnebose R, Lorenzini A, Sell C. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. Geroscience. 2019; 41:861–69. 10.1007/s11357-019-00113-y - DOI - PMC - PubMed

[6] Chung CL, Lawrence I, Hoffman M, Elgindi D, Nadhan K, Potnis M, Jin A, Sershon C, Binnebose R, Lorenzini A, Sell C. Topical rapamycin reduces markers of senescence and aging in human skin: an exploratory, prospective, randomized trial. Geroscience. 2019; 41:861–69. 10.1007/s11357-019-00113-y - DOI - PMC - PubMed

[7] Meingassner JG, Stütz A. Immunosuppressive macrolides of the type FK 506: a novel class of topical agents for treatment of skin diseases? J Invest Dermatol. 1992; 98:851–55. 10.1111/1523-1747.ep12456939 - DOI - PubMed

[8] Meingassner JG, Stütz A. Immunosuppressive macrolides of the type FK 506: a novel class of topical agents for treatment of skin diseases? J Invest Dermatol. 1992; 98:851–55. 10.1111/1523-1747.ep12456939 - DOI - PubMed

[9] Ormerod AD, Shah SA, Copeland P, Omar G, Winfield A. Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial. Br J Dermatol. 2005; 152:758–64. 10.1111/j.1365-2133.2005.06438.x - DOI - PubMed

[10] Ormerod AD, Shah SA, Copeland P, Omar G, Winfield A. Treatment of psoriasis with topical sirolimus: preclinical development and a randomized, double-blind trial. Br J Dermatol. 2005; 152:758–64. 10.1111/j.1365-2133.2005.06438.x - DOI - PubMed

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Rapamycin for the aging skin

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