Structural insights into group II TRP channels
- PMID: 31841954
- DOI: 10.1016/j.ceca.2019.102107
Structural insights into group II TRP channels
Abstract
The seven members of the TRP channel superfamily are divided into two main groups with five members comprising group I (TRPC/V/M/N/A) and TRPML (TRP MucoLipin) and TRPP (TRP Polycystin) making up group II. Group II channels share a high sequence homology on their transmembrane domains and are distinct from group I members as they contain a large luminal/extracellular domain between transmembrane helix 1 (S1) and S2. Since 2016, there are more than ten research papers reporting various structures of group II channels by either cryo-EM or X-ray crystallography. These studies along with recent functional analysis by the other groups have considerably strengthened our knowledge on TRPML and TRPP channels. In this review, we summarize and discuss these reports providing molecular insights into the group II TRP channel family.
Keywords: Cryo-EM structure; Mucolipidosis; PKD; Polycystin; TRPML; TRPP.
Copyright © 2019 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest M.F is partially supported by the Casma Therapeutics and X.L receives the consultant income and holds the share from Casma Therapeutics on the study of TRPML1.
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