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Review
. 2020 Feb;47(2):104-113.
doi: 10.1111/1346-8138.15184. Epub 2019 Dec 13.

Dendritic cells: The driver of psoriasis

Ao Wang  1   2 , YanPing Bai  1   2
Affiliations
Review

Dendritic cells: The driver of psoriasis

Ao Wang et al. J Dermatol. 2020 Feb.

Abstract

Psoriasis is a chronic skin inflammatory disorder, the immune mechanism of which has been profoundly elucidated in the past few years. The dominance of the interleukin (IL)-23/IL-17 axis is a significant breakthrough in the understanding of the pathogenesis of psoriasis, and treatment targeting IL-23 and IL-17 has successfully benefited patients with the disease. The skin contains a complex network of dendritic cells (DC) mainly composed of epidermal Langerhans cells, bone marrow-derived dermal conventional DC, plasmacytoid DC and inflammatory DC. As the prominent cellular source of α-interferon, tumor necrosis factor-α, IL-12 and IL-23, DC play a pivotal role in psoriasis. Thus, targeting pathogenic DC subsets is a valid strategy for alleviating and preventing psoriasis and other DC-derived diseases. In this review, we survey the known role of DC in this disease.

Keywords: Langerhans cells; dendritic cells; interleukin-23; psoriasis; α-interferon.

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