Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy

doi:10.1007/s00253-019-10257-8

Review

. 2020 Jan;104(2):575-587.

doi: 10.1007/s00253-019-10257-8. Epub 2019 Dec 12.

Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy

Zhenru Xu¹, Xu Han², Daming Ou¹, Ting Liu¹, Zunxiong Li³, Guanmin Jiang⁴, Jing Liu⁵, Ji Zhang⁶

Affiliations

¹ Department of Rheumatology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
² Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
³ University of South China, Hengyang, Hunan, China.
⁴ Department of Clinical Laboratory, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.
⁵ Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China. jingliucsu@hotmail.com.
⁶ Department of Rheumatology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China. zhang_ji001@hotmail.com.

PMID: 31832711
DOI: 10.1007/s00253-019-10257-8

Review

Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy

Zhenru Xu et al. Appl Microbiol Biotechnol. 2020 Jan.

. 2020 Jan;104(2):575-587.

doi: 10.1007/s00253-019-10257-8. Epub 2019 Dec 12.

Authors

Zhenru Xu¹, Xu Han², Daming Ou¹, Ting Liu¹, Zunxiong Li³, Guanmin Jiang⁴, Jing Liu⁵, Ji Zhang⁶

Affiliations

¹ Department of Rheumatology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China.
² Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China.
³ University of South China, Hengyang, Hunan, China.
⁴ Department of Clinical Laboratory, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China.
⁵ Molecular Biology Research Center & Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, Hunan, China. jingliucsu@hotmail.com.
⁶ Department of Rheumatology, The First Affiliated Hospital of University of South China, Hengyang, Hunan, China. zhang_ji001@hotmail.com.

PMID: 31832711
DOI: 10.1007/s00253-019-10257-8

Abstract

Autophagy is a highly conserved catabolic process and participates in a variety of cellular biological activities. The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway, as a critical regulator of autophagy, is involved in the initiation and promotion of a series of pathological disorders including various tumors. Autophagy also participates in regulating the balance between the tumor and the tumor microenvironment. Natural products have been considered a treasure of new drug discoveries and are of great value to medicine. Mounting evidence has suggested that numerous natural products are targeting PI3K/AKT/mTOR-mediated autophagy, thereby suppressing tumor growth. Furthermore, autophagy plays a "double-edged sword" role in different tumors. Targeting PI3K/AKT/mTOR-mediated autophagy is an important therapeutic strategy for a variety of tumors, and plays important roles in enhancing the chemosensitivity of tumor cells and avoiding drug resistance. Therefore, we summarized the roles of PI3K/AKT/mTOR-mediated autophagy in tumorigenesis, progression, and drug resistance of tumors, which may be utilized to design preferably therapeutic strategies for various tumors.

Keywords: Autophagy; Drug resistance; PI3K/AKT/mTOR; Tumor; Tumor microenvironment.

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Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy

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Targeting PI3K/AKT/mTOR-mediated autophagy for tumor therapy

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