Functional proteins of mesenchymal stem cell-derived extracellular vesicles

doi:10.1186/s13287-019-1484-6

Review

. 2019 Nov 28;10(1):359.

doi: 10.1186/s13287-019-1484-6.

Functional proteins of mesenchymal stem cell-derived extracellular vesicles

Guanguan Qiu¹, Guoping Zheng¹, Menghua Ge¹, Jiangmei Wang², Ruoqiong Huang², Qiang Shu³, Jianguo Xu^{4

5}

Affiliations

¹ Shaoxing Second Hospital, 123 Yanan Road, Shaoxing, 312000, Zhejiang, China.
² The Children's Hospital of Zhejiang University School of Medicine, 3333 Binsheng Road, Hangzhou, 310051, Zhejiang, China.
³ The Children's Hospital of Zhejiang University School of Medicine, 3333 Binsheng Road, Hangzhou, 310051, Zhejiang, China. shuqiang@zju.edu.cn.
⁴ Shaoxing Second Hospital, 123 Yanan Road, Shaoxing, 312000, Zhejiang, China. jxu5@yahoo.com.
⁵ The First Affiliated Hospital of Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. jxu5@yahoo.com.

PMID: 31779700
PMCID: PMC6883709
DOI: 10.1186/s13287-019-1484-6

Review

Functional proteins of mesenchymal stem cell-derived extracellular vesicles

Guanguan Qiu et al. Stem Cell Res Ther. 2019.

. 2019 Nov 28;10(1):359.

doi: 10.1186/s13287-019-1484-6.

Authors

Guanguan Qiu¹, Guoping Zheng¹, Menghua Ge¹, Jiangmei Wang², Ruoqiong Huang², Qiang Shu³, Jianguo Xu^{4

5}

Affiliations

¹ Shaoxing Second Hospital, 123 Yanan Road, Shaoxing, 312000, Zhejiang, China.
² The Children's Hospital of Zhejiang University School of Medicine, 3333 Binsheng Road, Hangzhou, 310051, Zhejiang, China.
³ The Children's Hospital of Zhejiang University School of Medicine, 3333 Binsheng Road, Hangzhou, 310051, Zhejiang, China. shuqiang@zju.edu.cn.
⁴ Shaoxing Second Hospital, 123 Yanan Road, Shaoxing, 312000, Zhejiang, China. jxu5@yahoo.com.
⁵ The First Affiliated Hospital of Zhejiang University School of Medicine, 79 Qingchun Road, Hangzhou, 310003, Zhejiang, China. jxu5@yahoo.com.

PMID: 31779700
PMCID: PMC6883709
DOI: 10.1186/s13287-019-1484-6

Abstract

Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs, and phospholipids, and are a novel mechanism of intercellular communication. It has been proposed that the immunomodulatory and regenerative effects of mesenchymal stem/stromal cells (MSCs) are mainly mediated by soluble paracrine factors and MSC-derived EVs (MSC-EVs). Recent studies suggest that MSC-EVs may serve as a novel and cell-free alternative to whole-cell therapies. The focus of this review is to discuss the functional proteins which facilitate the effects of MSC-EVs. The first section of the review discusses the general functions of EV proteins. Next, we describe the proteomics of MSC-EVs as compared with their parental cells. Then, the review presents the current knowledge that protein contents of MSC-EVs play an essential role in immunomodulation and treatment of various diseases. In summary, functional protein components are at least partially responsible for disease-modulating capacity of MSC-EVs.

Keywords: Exosomes; Extracellular vesicles; Functional proteins; Mesenchymal stem/stromal cells; Microvesicles.

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Conflict of interest statement

The authors declare that they have no competing interests.

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References

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[1] Zheng G, Huang L, Tong H, Shu Q, Hu Y, Ge M, Deng K, Zhang L, Zou B, Cheng B, Xu J. Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study. Respir Res. 2014;15:39. doi: 10.1186/1465-9921-15-39. - DOI - PMC - PubMed

[2] Zheng G, Huang L, Tong H, Shu Q, Hu Y, Ge M, Deng K, Zhang L, Zou B, Cheng B, Xu J. Treatment of acute respiratory distress syndrome with allogeneic adipose-derived mesenchymal stem cells: a randomized, placebo-controlled pilot study. Respir Res. 2014;15:39. doi: 10.1186/1465-9921-15-39. - DOI - PMC - PubMed

[3] Florea V, Rieger AC, DiFede DL, El-Khorazaty J, Natsumeda M, Banerjee MN, Tompkins BA, Khan A, Schulman IH, Landin AM, et al. Dose comparison study of allogeneic mesenchymal stem cells in patients with ischemic cardiomyopathy (the TRIDENT study) Circ Res. 2017;121:1279–1290. doi: 10.1161/CIRCRESAHA.117.311827. - DOI - PMC - PubMed

[4] Florea V, Rieger AC, DiFede DL, El-Khorazaty J, Natsumeda M, Banerjee MN, Tompkins BA, Khan A, Schulman IH, Landin AM, et al. Dose comparison study of allogeneic mesenchymal stem cells in patients with ischemic cardiomyopathy (the TRIDENT study) Circ Res. 2017;121:1279–1290. doi: 10.1161/CIRCRESAHA.117.311827. - DOI - PMC - PubMed

[5] Smets Françoise, Dobbelaere Dries, McKiernan Patrick, Dionisi-Vici Carlo, Broué Pierre, Jacquemin Emmanuel, Lopes Ana Isabel, Gonçalves Isabel, Mandel Hanna, Pawlowska Joanna, Kamińska Diana, Shteyer Eyal, Torre Giuliano, Shapiro Riki, Eyskens François, Clapuyt Philippe, Gissen Paul, Pariente Danièle, Grunewald Stephanie, Yudkoff Marc, Binda Maria Mercedes, Najimi Mustapha, Belmonte Nathalie, de Vos Beatrice, Thonnard Joelle, Sokal Etienne. Phase I/II Trial of Liver–derived Mesenchymal Stem Cells in Pediatric Liver–based Metabolic Disorders. Transplantation. 2019;103(9):1903–1915. doi: 10.1097/TP.0000000000002605. - DOI - PubMed

[6] Smets Françoise, Dobbelaere Dries, McKiernan Patrick, Dionisi-Vici Carlo, Broué Pierre, Jacquemin Emmanuel, Lopes Ana Isabel, Gonçalves Isabel, Mandel Hanna, Pawlowska Joanna, Kamińska Diana, Shteyer Eyal, Torre Giuliano, Shapiro Riki, Eyskens François, Clapuyt Philippe, Gissen Paul, Pariente Danièle, Grunewald Stephanie, Yudkoff Marc, Binda Maria Mercedes, Najimi Mustapha, Belmonte Nathalie, de Vos Beatrice, Thonnard Joelle, Sokal Etienne. Phase I/II Trial of Liver–derived Mesenchymal Stem Cells in Pediatric Liver–based Metabolic Disorders. Transplantation. 2019;103(9):1903–1915. doi: 10.1097/TP.0000000000002605. - DOI - PubMed

[7] Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750. doi: 10.1080/20013078.2018.1535750. - DOI - PMC - PubMed

[8] Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, et al. Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. J Extracell Vesicles. 2018;7:1535750. doi: 10.1080/20013078.2018.1535750. - DOI - PMC - PubMed

[9] Hessvik NP, Llorente A. Current knowledge on exosome biogenesis and release. Cell Mol Life Sci. 2018;75:193–208. doi: 10.1007/s00018-017-2595-9. - DOI - PMC - PubMed

[10] Hessvik NP, Llorente A. Current knowledge on exosome biogenesis and release. Cell Mol Life Sci. 2018;75:193–208. doi: 10.1007/s00018-017-2595-9. - DOI - PMC - PubMed

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Functional proteins of mesenchymal stem cell-derived extracellular vesicles

Affiliations

Functional proteins of mesenchymal stem cell-derived extracellular vesicles

Authors

Affiliations

Abstract

Conflict of interest statement

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