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Review
. 2019 Dec;33(4):953-976.
doi: 10.1016/j.idc.2019.08.005.

Ebola Virus Disease: Epidemiology, Clinical Features, Management, and Prevention

Emanuele Nicastri  1 , Gary Kobinger  2 , Francesco Vairo  1 , Chiara Montaldo  1 , Leonard E G Mboera  3 , Rashid Ansunama  4 , Alimuddin Zumla  5 , Giuseppe Ippolito  6
Affiliations
Review

Ebola Virus Disease: Epidemiology, Clinical Features, Management, and Prevention

Emanuele Nicastri et al. Infect Dis Clin North Am. 2019 Dec.

Abstract

Ebola virus disease (EVD) is a deadly zoonotic disease caused by the Ebola virus. There is no specific treatment approved for EVD. Supportive care and management of complications are mainstays of treatment. Effective outbreak control requires a multidisciplinary team effort applying case management, infection prevention and control practices, surveillance and contact tracing, a good laboratory service, safe and dignified burials, and social and community mobilization. This article highlights the epidemiology, clinical features, diagnosis, management, and prevention of EVD. The emerging diagnostic technologies, rapid viral characterization, geospatial mapping of EVD transmission, and new treatments and vaccines are discussed.

Keywords: Diagnosis; Ebola; Ebola hemorrhagic fever; Ebola virus diseases; Epidemiology; Prevention; Treatment; Vaccines.

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