Treatment of sepsis-induced acute kidney injury in the ICU: the therapeutic targets do not seem to be established yet

doi:10.21037/atm.2019.07.66

Editorial

. 2019 Sep;7(Suppl 6):S181.

doi: 10.21037/atm.2019.07.66.

Treatment of sepsis-induced acute kidney injury in the ICU: the therapeutic targets do not seem to be established yet

Jean-Pierre Quenot^{1

2

3

4

5

6}, Auguste Dargent^{1

2}, Audrey Large¹, Jean-Baptiste Roudaut¹, Pascal Andreu¹, Saber Barbar^{7

8}

Affiliations

¹ Service de Médecine Intensive-Réanimation, CHU Dijon Bourgogne, France.
² INSERM, U1231, Equipe Lipness, Dijon, France.
³ Université Bourgogne-Franche-Comté, UMR1231 Lipides, Nutrition, Cancer, équipe Lipness, Dijon, France.
⁴ LipSTIC LabEx, Fondation de coopération scientifique Bourgogne-Franche-Comté, Dijon, France.
⁵ INSERM, CIC 1432, Module Epidémiologie Clinique, Dijon, France.
⁶ CHU Dijon-Bourgogne, Centre d'Investigation Clinique, Module Epidémiologie Clinique/Essais Cliniques, Dijon, France.
⁷ Service de Réanimation, CHU de Nîmes, France.
⁸ Université de Montpellier, Faculté de Médecine de Montpellier-Nîmes, EA 2992, Nîmes, France.

PMID: 31656760
PMCID: PMC6789372
DOI: 10.21037/atm.2019.07.66

Editorial

Treatment of sepsis-induced acute kidney injury in the ICU: the therapeutic targets do not seem to be established yet

Jean-Pierre Quenot et al. Ann Transl Med. 2019 Sep.

. 2019 Sep;7(Suppl 6):S181.

doi: 10.21037/atm.2019.07.66.

Authors

Jean-Pierre Quenot^{1

2

3

4

5

6}, Auguste Dargent^{1

2}, Audrey Large¹, Jean-Baptiste Roudaut¹, Pascal Andreu¹, Saber Barbar^{7

8}

Affiliations

¹ Service de Médecine Intensive-Réanimation, CHU Dijon Bourgogne, France.
² INSERM, U1231, Equipe Lipness, Dijon, France.
³ Université Bourgogne-Franche-Comté, UMR1231 Lipides, Nutrition, Cancer, équipe Lipness, Dijon, France.
⁴ LipSTIC LabEx, Fondation de coopération scientifique Bourgogne-Franche-Comté, Dijon, France.
⁵ INSERM, CIC 1432, Module Epidémiologie Clinique, Dijon, France.
⁶ CHU Dijon-Bourgogne, Centre d'Investigation Clinique, Module Epidémiologie Clinique/Essais Cliniques, Dijon, France.
⁷ Service de Réanimation, CHU de Nîmes, France.
⁸ Université de Montpellier, Faculté de Médecine de Montpellier-Nîmes, EA 2992, Nîmes, France.

PMID: 31656760
PMCID: PMC6789372
DOI: 10.21037/atm.2019.07.66

No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Comment on

Effect of Human Recombinant Alkaline Phosphatase on 7-Day Creatinine Clearance in Patients With Sepsis-Associated Acute Kidney Injury: A Randomized Clinical Trial.
Pickkers P, Mehta RL, Murray PT, Joannidis M, Molitoris BA, Kellum JA, Bachler M, Hoste EAJ, Hoiting O, Krell K, Ostermann M, Rozendaal W, Valkonen M, Brealey D, Beishuizen A, Meziani F, Murugan R, de Geus H, Payen D, van den Berg E, Arend J; STOP-AKI Investigators. Pickkers P, et al. JAMA. 2018 Nov 20;320(19):1998-2009. doi: 10.1001/jama.2018.14283. JAMA. 2018. PMID: 30357272 Free PMC article. Clinical Trial.

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References

1. Hoste EA, Bagshaw SM, Bellomo R, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med 2015;41:1411-23. 10.1007/s00134-015-3934-7 - DOI - PubMed
1. Quenot JP, Binquet C, Kara F, et al. The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study. Crit Care 2013;17:R65. 10.1186/cc12598 - DOI - PMC - PubMed
1. Chawla LS, Eggers PW, Star RA, et al. Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 2014;371:58-66. 10.1056/NEJMra1214243 - DOI - PMC - PubMed
1. Bagshaw SM, George C, Bellomo R, et al. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008;12:R47. 10.1186/cc6863 - DOI - PMC - PubMed
1. Barbar SD, Clere-Jehl R, Bourredjem A, et al. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. N Engl J Med 2018;379:1431-42. 10.1056/NEJMoa1803213 - DOI - PubMed

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[1] Hoste EA, Bagshaw SM, Bellomo R, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med 2015;41:1411-23. 10.1007/s00134-015-3934-7 - DOI - PubMed

[2] Hoste EA, Bagshaw SM, Bellomo R, et al. Epidemiology of acute kidney injury in critically ill patients: the multinational AKI-EPI study. Intensive Care Med 2015;41:1411-23. 10.1007/s00134-015-3934-7 - DOI - PubMed

[3] Quenot JP, Binquet C, Kara F, et al. The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study. Crit Care 2013;17:R65. 10.1186/cc12598 - DOI - PMC - PubMed

[4] Quenot JP, Binquet C, Kara F, et al. The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study. Crit Care 2013;17:R65. 10.1186/cc12598 - DOI - PMC - PubMed

[5] Chawla LS, Eggers PW, Star RA, et al. Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 2014;371:58-66. 10.1056/NEJMra1214243 - DOI - PMC - PubMed

[6] Chawla LS, Eggers PW, Star RA, et al. Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med 2014;371:58-66. 10.1056/NEJMra1214243 - DOI - PMC - PubMed

[7] Bagshaw SM, George C, Bellomo R, et al. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008;12:R47. 10.1186/cc6863 - DOI - PMC - PubMed

[8] Bagshaw SM, George C, Bellomo R, et al. Early acute kidney injury and sepsis: a multicentre evaluation. Crit Care 2008;12:R47. 10.1186/cc6863 - DOI - PMC - PubMed

[9] Barbar SD, Clere-Jehl R, Bourredjem A, et al. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. N Engl J Med 2018;379:1431-42. 10.1056/NEJMoa1803213 - DOI - PubMed

[10] Barbar SD, Clere-Jehl R, Bourredjem A, et al. Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis. N Engl J Med 2018;379:1431-42. 10.1056/NEJMoa1803213 - DOI - PubMed

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Treatment of sepsis-induced acute kidney injury in the ICU: the therapeutic targets do not seem to be established yet

Affiliations

Treatment of sepsis-induced acute kidney injury in the ICU: the therapeutic targets do not seem to be established yet

Authors

Affiliations

Conflict of interest statement

Comment on

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