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. 2019 Dec;42(12):2211-2219.
doi: 10.2337/dc19-0532. Epub 2019 Sep 19.

Racial/Ethnic Disparities in the Prevalence of Diabetes and Prediabetes by BMI: Patient Outcomes Research To Advance Learning (PORTAL) Multisite Cohort of Adults in the U.S

Yeyi Zhu  1   2 , Margo A Sidell  3 , David Arterburn  4 , Matthew F Daley  5 , Jay Desai  6 , Stephanie L Fitzpatrick  7 , Michael A Horberg  8 , Corinna Koebnick  3 , Emily McCormick  9 , Caryn Oshiro  10 , Deborah R Young  3 , Assiamira Ferrara  11
Affiliations

Racial/Ethnic Disparities in the Prevalence of Diabetes and Prediabetes by BMI: Patient Outcomes Research To Advance Learning (PORTAL) Multisite Cohort of Adults in the U.S

Yeyi Zhu et al. Diabetes Care. 2019 Dec.

Abstract

Objective: To examine racial/ethnic disparities in the prevalence of diabetes and prediabetes by BMI category.

Research design and methods: In a consortium of three U.S. integrated health care systems, 4,906,238 individuals aged ≥20 years during 2012-2013 were included. Diabetes and prediabetes were ascertained by diagnosis and laboratory results; antihyperglycemic medications were also included for diabetes ascertainment.

Results: The age-standardized diabetes and prediabetes prevalence estimates were 15.9% and 33.4%, respectively. Diabetes but not prediabetes prevalence increased across BMI categories among all racial/ethnic groups (P for trend < 0.001). Racial/ethnic minorities reached a given diabetes prevalence at lower BMIs than whites; Hawaiians/Pacific Islanders and Asians had a diabetes prevalence of 24.6% (95% CI 24.1-25.2%) in overweight and 26.5% (26.3-26.8%) in obese class 1, whereas whites had a prevalence of 23.7% (23.5-23.8%) in obese class 2. The age-standardized prediabetes prevalence estimates in overweight among Hispanics (35.6% [35.4-35.7%]), Asians (38.1% [38.0-38.3%]), and Hawaiians/Pacific Islanders (37.5% [36.9-38.2%]) were similar to those in obese class 4 among whites (35.3% [34.5-36.0%]), blacks (36.8% [35.5-38.2%]), and American Indians/Alaskan Natives (34.2% [29.6-38.8%]). In adjusted models, the strength of association between BMI and diabetes was highest among whites (relative risk comparing obese class 4 with normal weight 7.64 [95% CI 7.50-7.79]) and lowest among blacks (3.16 [3.05-3.27]). The association between BMI and prediabetes was less pronounced.

Conclusions: Racial/ethnic minorities had a higher burden of diabetes and prediabetes at lower BMIs than whites, suggesting the role of factors other than obesity in racial/ethnic disparities in diabetes and prediabetes risk and highlighting the need for tailored screening and prevention strategies.

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Figures

Figure 1
Figure 1
Adjusted RRs (95% CIs) of diabetes by race/ethnicity and BMI categories in a logarithmic scale. Non-Asians were categorized as underweight (UW) (BMI <18.5 kg/m2), normal weight (NW) (18.5–24.9 kg/m2), overweight (OW) (25.0–29.9 kg/m2), and obese class (OC) 1–4 (30.0–34.9, 35.0–39.9, 40.0–49.9, ≥50.0 kg/m2), and Asians were categorized as UW (<18.5 kg/m2), NW (18.5–22.9 kg/m2), OW (23.0–27.4 kg/m2), and OC 1–4 (27.5–32.4, 32.5–37.4, 37.5–47.4, ≥47.5 kg/m2). Risk estimates were adjusted for age, sex, neighborhood poverty, neighborhood education, and site. Across BMI categories, P for trend < 0.001 for all groups after FDR adjustment for multiple comparisons. *P for interaction < 0.001 between race/ethnicity and BMI categories.
Figure 2
Figure 2
Adjusted RRs (95% CIs) of prediabetes by race/ethnicity and BMI categories in a logarithmic scale. Non-Asians were categorized as underweight (UW) (BMI <18.5 kg/m2), normal weight (NW) (18.5–24.9 kg/m2), overweight (OW) (25.0–29.9 kg/m2), and obese class (OC) 1–4 (30.0–34.9, 35.0–39.9, 40.0–49.9, ≥50.0 kg/m2), and Asians were categorized as UW (<18.5 kg/m2), NW (18.5–22.9 kg/m2), OW (23.0–27.4 kg/m2), and OC 1–4 (27.5–32.4, 32.5–37.4, 37.5–47.4, ≥47.5 kg/m2). Risk estimates were adjusted for age, sex, neighborhood poverty, neighborhood education, and site. Across BMI categories, P for trend < 0.001 for all groups after FDR adjustment for multiple comparisons. *P for interaction < 0.001 between race/ethnicity and BMI categories.
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