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. 2019 Feb;14(2):107-122.
doi: 10.2217/fvl-2018-0161. Epub 2019 Jan 21.

Tripartite motif proteins: an emerging antiviral protein family

Girish Patil  1 , Shitao Li  1
Affiliations

Tripartite motif proteins: an emerging antiviral protein family

Girish Patil et al. Future Virol. 2019 Feb.
No abstract available

Keywords: RING domain; adaptive immunity; host defense; host restriction; innate immunity; intrinsic immunity; protein interaction; ubiquitination; virulence.

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Figures

Figure 1.
Figure 1.. The schematics of the subgroups of TRIM proteins.
Each number in the column of TRIM Family Members is corresponding to the designated TRIM protein number. For example, 1 stands for TRIM1.
Figure 2.
Figure 2.. The process of ubiquitination.
Ubiquitin is first activated by a ubiquitin-activating enzyme (E1) in an ATP-dependent reaction. The activated ubiquitin is then transferred to a ubiquitin-conjugating enzyme (E2). Subsequently, the E2-E3 enzyme complex conjugates one or more ubiquitin proteins to the substrate.
Figure 3.
Figure 3.. The role of TRIM proteins in intrinsic immunity.
This figure illustrates that TRIM proteins employ distinct mechanisms to inhibit viral entry, replication or dissemination by interacting with viral proteins.
Figure 4.
Figure 4.. The role of TRIM proteins in innate immunity.
This figure illustrates that TRIM proteins play both positive and negative roles in TLR, RLR and cGAS signaling pathways.
See this image and copyright information in PMC

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References

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