Comparative Study
doi: 10.1126/science.3136546.
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
Affiliations
- PMID: 3136546
- DOI: 10.1126/science.3136546
Item in Clipboard
Comparative Study
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor
Science.
.
Abstract
Interleukin-6 (IL-6/BSF-2/IFN beta 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of approximately 19 amino acids and a domain of approximately 90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of approximately 82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
Similar articles
-
Molecular cloning and expression of the human interleukin 5 receptor.J Exp Med. 1992 Feb 1;175(2):341-51. doi: 10.1084/jem.175.2.341. J Exp Med. 1992. PMID: 1732409 Free PMC article.
-
Molecular cloning, characterization and functional expression of the rat liver interleukin 6 receptor.J Biol Chem. 1990 Nov 15;265(32):19853-62. J Biol Chem. 1990. PMID: 2174054
-
Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily.Cell. 1990 Mar 23;60(6):941-51. doi: 10.1016/0092-8674(90)90342-c. Cell. 1990. PMID: 2317865
-
A multifunctional cytokine (IL-6/BSF-2) and its receptor.Int Arch Allergy Appl Immunol. 1989;88(1-2):29-33. doi: 10.1159/000234743. Int Arch Allergy Appl Immunol. 1989. PMID: 2651317 Review.
-
Structure and function of IL-2 and IL-2 receptors.Behring Inst Mitt. 1992 Apr;(91):87-95. Behring Inst Mitt. 1992. PMID: 1524574 Review.
Cited by
-
Interleukin-6 (IL-6) mediated the increased contraction of distal colon in streptozotocin-induced diabetes in rats via IL-6 receptor pathway.Int J Clin Exp Pathol. 2015 May 1;8(5):4514-24. eCollection 2015. Int J Clin Exp Pathol. 2015. PMID: 26191141 Free PMC article.
-
Host Responses in the Link Between Periodontitis and Rheumatoid Arthritis.Curr Oral Health Rep. 2015;2(1):1-8. doi: 10.1007/s40496-014-0039-2. Curr Oral Health Rep. 2015. PMID: 25657893 Free PMC article. Review.
-
Function and heterogeneity of human Fc receptors for immunoglobulin G.J Clin Invest. 1989 Feb;83(2):355-61. doi: 10.1172/JCI113891. J Clin Invest. 1989. PMID: 2643627 Free PMC article. Review. No abstract available.
-
Unregulated expression of the erythropoietin receptor gene caused by insertion of spleen focus-forming virus long terminal repeat in a murine erythroleukemia cell line.Mol Cell Biol. 1991 Nov;11(11):5527-33. doi: 10.1128/mcb.11.11.5527-5533.1991. Mol Cell Biol. 1991. PMID: 1656233 Free PMC article.
-
Interleukin-6 and the acute phase response.Biochem J. 1990 Feb 1;265(3):621-36. doi: 10.1042/bj2650621. Biochem J. 1990. PMID: 1689567 Free PMC article. Review. No abstract available.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Research Materials
