Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review

doi:10.1007/s10689-019-00135-7

. 2019 Oct;18(4):399-420.

doi: 10.1007/s10689-019-00135-7. Epub 2019 Jun 24.

Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review

Adriana M Coletta^{1

2

3}, Susan K Peterson¹, Leticia A Gatus¹, Kate J Krause⁴, Susan M Schembre^{1

5}, Susan C Gilchrist⁶, Mala Pande⁷, Eduardo Vilar⁶, Y Nancy You⁸, Miguel A Rodriguez-Bigas⁸, Larkin L Strong⁹, Patrick M Lynch⁷, Karen H Lu¹⁰, Karen Basen-Engquist^{11

12}

Affiliations

¹ Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
² Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, UT, USA.
³ Department of Health, Kinesiology, and Recreation, The University of Utah, Salt Lake City, UT, USA.
⁴ Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁵ Department of Family and Community Medicine, College of Medicine-Tucson, University of Arizona, Tucson, AZ, 85724, USA.
⁶ Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁷ Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁸ Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁹ Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
¹⁰ Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
¹¹ Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. kbasenen@mdanderson.org.
¹² The University of Texas MD Anderson Cancer Center, Unit 1330, P.O. Box 301439, Houston, TX, 77230-1439, USA. kbasenen@mdanderson.org.

PMID: 31236808
PMCID: PMC6863045
DOI: 10.1007/s10689-019-00135-7

Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review

Adriana M Coletta et al. Fam Cancer. 2019 Oct.

. 2019 Oct;18(4):399-420.

doi: 10.1007/s10689-019-00135-7. Epub 2019 Jun 24.

Authors

Affiliations

¹ Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
² Cancer Control and Population Sciences Program, Huntsman Cancer Institute, Salt Lake City, UT, USA.
³ Department of Health, Kinesiology, and Recreation, The University of Utah, Salt Lake City, UT, USA.
⁴ Research Medical Library, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁵ Department of Family and Community Medicine, College of Medicine-Tucson, University of Arizona, Tucson, AZ, 85724, USA.
⁶ Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁷ Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁸ Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
⁹ Department of Health Disparities Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
¹⁰ Department of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
¹¹ Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. kbasenen@mdanderson.org.
¹² The University of Texas MD Anderson Cancer Center, Unit 1330, P.O. Box 301439, Houston, TX, 77230-1439, USA. kbasenen@mdanderson.org.

PMID: 31236808
PMCID: PMC6863045
DOI: 10.1007/s10689-019-00135-7

Abstract

Lifestyle factors related to energy balance, such as excess body weight, poor diet, and physical inactivity, are associated with risk of sporadic endometrial cancer (EC) and colorectal cancer (CRC). There are limited data on energy balance-related lifestyle factors and EC or CRC risk among individuals with lynch syndrome, who are at extraordinarily higher risk of developing EC or CRC. We conducted a systematic review of evidence related to weight status, weight change, dietary habits, and physical activity on EC and CRC risk among individuals with lynch syndrome. Findings are reported narratively. We searched Medline, EMBASE, CENTRAL, PubMed, and clinicaltrials.gov up to June 14th, 2018. In total, 1060 studies were identified and 16 were included. Three studies were related to EC and 13 to CRC. Overall, evidence suggests that weight status/weight change may not be associated with EC risk and multivitamin and folic-acid supplementation may be associated with decreased EC risk. Early-adulthood overweight/obese weight-status and adulthood weight-gain may be associated with increased CRC risk, whereas multivitamin supplementation, tea and high fruit intake, and physical activity may be associated with decreased CRC risk. Current evidence proposes that recommendations related to weight, some dietary habits, and physical activity recommended for the general public are also relevant to individuals with lynch syndrome. More research is needed, specifically prospective cohorts and randomized controlled trials, to determine if tailored recommendations are needed among individuals with lynch syndrome.

Keywords: Cancer risk; Diet; Exercise; Lynch; Weight.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to disclose

Figures

**Fig. 1**
PRISMA Flow Diagram MMR = mismatch repair; CRC = colorectal cancer; EC = endometrial cancer

See this image and copyright information in PMC

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References

1. Spira A, Yurgelun M, Alexandrov L, et al. Precancer atlas to drive precision prevention trials. Cancer Res. 2017;77(7):1510–41. 10.1158/0008-5472.CAN-16-2346 - DOI - PMC - PubMed
1. Aaltonen M, Staff S, Mecklin J, Pylvänäinen K, and Mäenpää J Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study. Mol Clin Oncol. 2017;6(5):758–64. 10.3892/mco.2017.1211 - DOI - PMC - PubMed
1. Aarnio M, Mecklin J, Aaltonen L, Nyström-Lahti M, and Järvinen H Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer. 1995;64(6):430–3. - PubMed
1. Lynch H, Lynch P, Lanspa S, et al. Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin Genet. 2009;76(1):1–18. 10.1111/j.1399-0004.2009.01230.x. - DOI - PMC - PubMed
1. Møller P, Seppälä T, Bernstein I, et al. Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. Gut. 2017. 10.1136/gutjnl-2017-314057 - DOI - PMC - PubMed

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[1] Spira A, Yurgelun M, Alexandrov L, et al. Precancer atlas to drive precision prevention trials. Cancer Res. 2017;77(7):1510–41. 10.1158/0008-5472.CAN-16-2346 - DOI - PMC - PubMed

[2] Spira A, Yurgelun M, Alexandrov L, et al. Precancer atlas to drive precision prevention trials. Cancer Res. 2017;77(7):1510–41. 10.1158/0008-5472.CAN-16-2346 - DOI - PMC - PubMed

[3] Aaltonen M, Staff S, Mecklin J, Pylvänäinen K, and Mäenpää J Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study. Mol Clin Oncol. 2017;6(5):758–64. 10.3892/mco.2017.1211 - DOI - PMC - PubMed

[4] Aaltonen M, Staff S, Mecklin J, Pylvänäinen K, and Mäenpää J Comparison of lifestyle, hormonal and medical factors in women with sporadic and Lynch syndrome-associated endometrial cancer: A retrospective case-case study. Mol Clin Oncol. 2017;6(5):758–64. 10.3892/mco.2017.1211 - DOI - PMC - PubMed

[5] Aarnio M, Mecklin J, Aaltonen L, Nyström-Lahti M, and Järvinen H Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer. 1995;64(6):430–3. - PubMed

[6] Aarnio M, Mecklin J, Aaltonen L, Nyström-Lahti M, and Järvinen H Life-time risk of different cancers in hereditary non-polyposis colorectal cancer (HNPCC) syndrome. Int J Cancer. 1995;64(6):430–3. - PubMed

[7] Lynch H, Lynch P, Lanspa S, et al. Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin Genet. 2009;76(1):1–18. 10.1111/j.1399-0004.2009.01230.x. - DOI - PMC - PubMed

[8] Lynch H, Lynch P, Lanspa S, et al. Review of the Lynch syndrome: history, molecular genetics, screening, differential diagnosis, and medicolegal ramifications. Clin Genet. 2009;76(1):1–18. 10.1111/j.1399-0004.2009.01230.x. - DOI - PMC - PubMed

[9] Møller P, Seppälä T, Bernstein I, et al. Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. Gut. 2017. 10.1136/gutjnl-2017-314057 - DOI - PMC - PubMed

[10] Møller P, Seppälä T, Bernstein I, et al. Cancer risk and survival in path_MMR carriers by gene and gender up to 75 years of age: a report from the Prospective Lynch Syndrome Database. Gut. 2017. 10.1136/gutjnl-2017-314057 - DOI - PMC - PubMed

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Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review

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Energy balance related lifestyle factors and risk of endometrial and colorectal cancer among individuals with lynch syndrome: a systematic review

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