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. 2019 Oct;16(5):1103-1111.
doi: 10.1111/iwj.13161. Epub 2019 Jun 17.

Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing

Jing Gao  1 , Liyun Wang  1 , Chuankai Xia  1 , Xingyu Yang  1 , Zhicheng Cao  1 , Lei Zheng  1 , Randy Ko  2 , Changbing Shen  3   4   5 , Chunjun Yang  1 , Cheng Cheng  6
Affiliations

Cold atmospheric plasma promotes different types of superficial skin erosion wounds healing

Jing Gao et al. Int Wound J. 2019 Oct.

Abstract

Superficial skin erosion wounds are very common in the clinic, and conventional treatments are not always effective; thus, effective and novel therapy is needed. Cold atmospheric plasma (CAP) has been recognised as a promising approach to wound healing. The purpose of this study is to show the potential clinical application of CAP for the healing of different kinds of superficial skin wounds. Seven patients with different kinds of superficial skin wounds (two patients with pyoderma gangrenosum, two patients with trauma would, one patient with giant genital wart, one patient with diabetic foot, and one patient with chronic eczema) were recruited to this study. All patients accepted and received CAP treatment every other day till the wound healed. The expected results were complete wound healing after CAP treatment. All patients achieved complete wound healing after several rounds (range from two to eight) of CAP treatment, and there was no side effect observed. CAP may provide a new and effective choice to solve the problem of the healing of superficial wounds that are not only caused by trauma but also because of eczema. CAP has certain value in the treatment of superficial skin diseases in the future.

Keywords: cold atmospheric plasma; skin lesion; traumatic wound.

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Figures

Figure 1
Figure 1
Cold atmospheric plasma (CAP) treatment process and operation steps
Figure 2
Figure 2
A, Skin lesion of the first pyoderma gangrenosum (PG) patient before cold atmospheric plasma (CAP) treatment, B, skin appearance of the first PG patient after six rounds of CAP treatment, C, skin lesion of the second PG patient before CAP treatment, D, skin appearance of the second PG patient after eight rounds of CAP treatments
Figure 3
Figure 3
A, Skin lesion of patient 3 before cold atmospheric plasma (CAP) treatment, B, immediate appearance of skin lesions of patient 3 after three rounds of CAP treatments, C, skin lesion of patient 4 before CAP treatment, D, appearance of skin lesions of patient 4 after three rounds of CAP treatment
Figure 4
Figure 4
A, The large wart covered the entire perineum before cold atmospheric plasma (CAP) treatment, B, immediate perineum wound after holmium laser treatment, and C, the wound of the entire perineum basically healed after two rounds of CAP treatment
Figure 5
Figure 5
A, Skin lesion of diabetic foot before cold atmospheric plasma (CAP) treatment and B, skin appearance of the patient after four rounds of CAP treatment
Figure 6
Figure 6
A, Skin lesion on the knee of patient with chronic eczema and B, skin appearance of the patient with chronic eczema after two rounds of cold atmospheric plasma treatment
See this image and copyright information in PMC

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