Exosome-Mediated Metastasis: Communication from a Distance

doi:10.1016/j.devcel.2019.04.011

Review

. 2019 May 6;49(3):347-360.

doi: 10.1016/j.devcel.2019.04.011.

Exosome-Mediated Metastasis: Communication from a Distance

Inbal Wortzel¹, Shani Dror¹, Candia M Kenific², David Lyden³

Affiliations

¹ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
² Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: cmk2009@med.cornell.edu.
³ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: dcl2001@med.cornell.edu.

PMID: 31063754
DOI: 10.1016/j.devcel.2019.04.011

Free article

Review

Exosome-Mediated Metastasis: Communication from a Distance

Inbal Wortzel et al. Dev Cell. 2019.

Free article

. 2019 May 6;49(3):347-360.

doi: 10.1016/j.devcel.2019.04.011.

Authors

Inbal Wortzel¹, Shani Dror¹, Candia M Kenific², David Lyden³

Affiliations

¹ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA.
² Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: cmk2009@med.cornell.edu.
³ Children's Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children's Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: dcl2001@med.cornell.edu.

PMID: 31063754
DOI: 10.1016/j.devcel.2019.04.011

Abstract

Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes.

Keywords: bone-marrow-derived cell; cancer; exosome; extracellular matrix; extracellular vesicle; immune cell; integrins; intercellular communication; metastasis; microvesicle; pre-metastatic niche; vascular leakiness.

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Exosome-Mediated Metastasis: Communication from a Distance

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Exosome-Mediated Metastasis: Communication from a Distance

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