Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)

doi:10.1016/j.lfs.2019.04.046

Review

. 2019 Jul 1:228:167-175.

doi: 10.1016/j.lfs.2019.04.046. Epub 2019 Apr 25.

Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)

Yan Li¹, Changye Chen², Yan Ma², Jiao Xiao³, Guifang Luo², Yukun Li⁴, Daichao Wu⁵

Affiliations

¹ Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, PR China; Reproductive and Genetic Hospital of Citic-Xiangya, Changsha, Hunan 410078, PR China.
² Department of Gynecology, The First Affiliated Hospital of University of South China, Hengyang 421001, PR China.
³ Department of Endocrinology, The Affiliated Nanhua Hospital, University of South China, Hengyang 421002, PR China.
⁴ Key Laboratory of Tumor Cellular and Molecular Pathology, College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, PR China; Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: yukun_li@foxmail.com.
⁵ Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, PR China; University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA. Electronic address: wudaichao@usc.edu.cn.

PMID: 31029778
DOI: 10.1016/j.lfs.2019.04.046

Review

Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)

Yan Li et al. Life Sci. 2019.

. 2019 Jul 1:228:167-175.

doi: 10.1016/j.lfs.2019.04.046. Epub 2019 Apr 25.

Authors

Yan Li¹, Changye Chen², Yan Ma², Jiao Xiao³, Guifang Luo², Yukun Li⁴, Daichao Wu⁵

Affiliations

¹ Institute of Reproductive and Stem Cell Engineering, School of Basic Medical Science, Central South University, Changsha, Hunan 410013, PR China; Reproductive and Genetic Hospital of Citic-Xiangya, Changsha, Hunan 410078, PR China.
² Department of Gynecology, The First Affiliated Hospital of University of South China, Hengyang 421001, PR China.
³ Department of Endocrinology, The Affiliated Nanhua Hospital, University of South China, Hengyang 421002, PR China.
⁴ Key Laboratory of Tumor Cellular and Molecular Pathology, College of Hunan Province, Cancer Research Institute, University of South China, Hengyang, Hunan 421001, PR China; Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, PR China. Electronic address: yukun_li@foxmail.com.
⁵ Clinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, PR China; University of Maryland Institute for Bioscience and Biotechnology Research, Rockville, MD 20850, USA. Electronic address: wudaichao@usc.edu.cn.

PMID: 31029778
DOI: 10.1016/j.lfs.2019.04.046

Abstract

Polycystic ovary syndrome (PCOS), a multisystem disease, is a major reason for female infertility around the world. It is no longer considered simply as a disease of ovary. Now researchers growing awareness of the multisystem features of this disease. PCOS has a higher relationship with metabolic disturbance and hypothalamic-pituitary-ovarian axis (HPOA) function disorders. This syndrome results in hyperandrogenemia (HA), hyperinsulinemia/insulin resistance (IR), increased estrone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) ratio imbalance, infertility, cardiovascular diseases, endometrial dysfunction, obesity, and including a litany of other health issues. Furthermore, PCOS has been garnered in recent times. Interventions like metformin, orlistat, hormonal contraceptives, GLP1 agonists, and VitD have been applied to ameliorate or reverse the pathological characterization of PCOS. Moreover, drug-combined therapy of PCOS is superior to single drug administration. This review will focus on the recent progress in pathogenesis and therapy of PCOS.

Keywords: AGEs; IR; IVF; PCOS; UPR; therapy.

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Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)

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Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)

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