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Review
. 2019 May;143(5):e20183517.
doi: 10.1542/peds.2018-3517.

Research Gaps in Primary Pediatric Hypertension

Perdita Taylor-Zapata  1 , Carissa M Baker-Smith  2 , Gilbert Burckart  3 , Stephen R Daniels  4 , Joseph T Flynn  5 , George Giacoia  6 , Dionna Green  7 , Aaron S Kelly  8 , Mona Khurana  9 , Jennifer S Li  10 , Charlotte Pratt  11 , Elaine M Urbina  12 , Anne Zajicek  13
Affiliations
Review

Research Gaps in Primary Pediatric Hypertension

Perdita Taylor-Zapata et al. Pediatrics. 2019 May.

Abstract

Hypertension affects >40% of the US population and is a major contributor to cardiovascular-related morbidity and mortality. Although less common among children and adolescents, hypertension affects 1% to 5% of all youth. The 2017 Clinical Practice Guideline for the Diagnosis and Management of High Blood Pressure in Children and Adolescents provided updates and strategies regarding the diagnosis and management of hypertension in youth. Despite this important information, many gaps in knowledge remain, such as the etiology, prevalence, and trends of hypertension; the utility and practicality of ambulatory blood pressure monitoring; practical goals for lifestyle modification that are generalizable; the long-term end-organ impacts of hypertension in youth; and the long-term safety and efficacy of antihypertensive therapy in youth. The Eunice Kennedy Shriver National Institute of Child Health and Human Development, in collaboration with the National Heart, Lung, and Blood Institute and the US Food and Drug Administration, sponsored a workshop of experts to discuss the current state of childhood primary hypertension. We highlight the results of that workshop and aim to (1) provide an overview of current practices related to the diagnosis, management, and treatment of primary pediatric hypertension; (2) identify related research gaps; and (3) propose ways to address existing research gaps.

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Conflict of interest statement

POTENTIAL CONFLICT OF INTEREST: Dr Baker-Smith was the methodologist and epidemiologist for the 2017 Clinical Practice Guideline for the Diagnosis and Management of High Blood Pressure in Children and Adolescents; Dr Daniels has served as a consultant for Sanofi and is the chair of a data monitoring and safety committee for Novo Nordisk; the other authors have indicated they have no potential conflicts of interest to disclose.

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