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. 2019 Jul-Aug:63-64:14-21.
doi: 10.1016/j.nut.2019.01.005. Epub 2019 Jan 15.

Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: A cross-sectional study

Ban-Hock Khor  1 , Sharmela Sahathevan  1 , Ayesha Sualeheen  1 , Mohammad Syafiq Md Ali  2 , Sreelakshmi Sankara Narayanan  3 , Karuthan Chinna  4 , Abdul Halim Abdul Gafor  5 , Bak-Leong Goh  6 , Ghazali Ahmad  7 , Zaki Morad  8 , Zulfitri Azuan Mat Daud  2 , Pramod Khosla  9 , Kalyana Sundram  10 , Tilakavati Karupaiah  11 ; for PaTCH Investigators
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Free article

Dietary fatty acid intake in hemodialysis patients and associations with circulating fatty acid profiles: A cross-sectional study

Ban-Hock Khor et al. Nutrition. 2019 Jul-Aug.
Free article

Abstract

Objectives: The aims of this study were threefold: first, to assess the dietary fatty acid (FA) intake and blood FA status in Malaysian patients on hemodialysis (HD); second, to examine the association between dietary FA intakes and blood FA profiles in patients on HD; and third, to determine whether blood FAs could serve as a biomarker of dietary fat intake quality in these patients.

Methods: Using 3 d of dietary records, FA intakes of 333 recruited patients were calculated using a food database built from laboratory analyses of commonly consumed Malaysian foods. Plasma triacylglycerol (TG) and erythrocyte FAs were determined by gas chromatography.

Results: High dietary saturated fatty acid (SFA) and monounsaturated fatty acid (MUFA) consumption trends were observed. Patients on HD also reported low dietary ω-3 and ω-6 polyunsaturated fatty acid (PUFA) consumptions and low levels of TG and erythrocyte FAs. TG and dietary FAs were significantly associated respective to total PUFA, total ω-6 PUFA, 18:2 ω-6, total ω-3 PUFA, 18:3 ω-3, 22:6 ω-3, and trans 18:2 isomers (P < 0.05). Contrarily, only dietary total ω-3 PUFA and 22:6 ω-3 were significantly associated with erythrocyte FAs (P < 0.01). The highest tertile of fish and shellfish consumption reflected a significantly higher proportion of TG 22:6 ω-3. Dietary SFAs were directly associated with TG and erythrocyte MUFA, whereas dietary PUFAs were not.

Conclusion: TG and erythrocyte FAs serve as biomarkers of dietary PUFA intake in patients on HD. Elevation of circulating MUFA may be attributed to inadequate intake of PUFAs.

Keywords: Circulating fatty acids; Dietary fat; Erythrocytes; Hemodialysis; Plasma.

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