Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1986 Oct;60(1):230-41.
doi: 10.1128/JVI.60.1.230-241.1986.

Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes

H T Cuypers, G C Selten, M Zijlstra, R E de Goede, C J Melief, A J Berns

Tumor progression in murine leukemia virus-induced T-cell lymphomas: monitoring clonal selections with viral and cellular probes

H T Cuypers et al. J Virol. 1986 Oct.

Abstract

Clonal selections occurring during the progression of Moloney murine leukemia virus (MuLV)-induced T-cell lymphomas in mice were examined in primary and transplanted tumors by monitoring various molecular markers: proviral integration patterns, MuLV insertions near c-myc and pim-1, and rearrangements of the immunoglobulin heavy chain and beta-chain T-cell receptor genes. The results were as follows. Moloney MuLV frequently induced oligoclonal tumors with proviral insertions near c-myc or pim-1 in the independent clones. Moloney MuLV acted as a highly efficient insertional mutagen, able to activate different (putative) oncogenes in one cell lineage. Clonal selections during tumor progression were frequently marked by the acquisition of new proviral integrations. Independent tumor cell clones exhibited a homing preference upon transplantation in syngeneic hosts and were differently affected by the route of transplantation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Nature. 1975 May 15;255(5505):197-200 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Oct;72(10):4008-12 - PubMed
    1. Proc Natl Acad Sci U S A. 1976 Jul;73(7):2448-52 - PubMed
    1. J Natl Cancer Inst. 1978 Jul;61(1):227-37 - PubMed
    1. Proc Natl Acad Sci U S A. 1979 Sep;76(9):4554-8 - PubMed

Publication types

MeSH terms

Substances