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Review
. 2018 Jul 28;1(2):100-108.
doi: 10.1002/ame2.12020. eCollection 2018 Jun.

Choosing the right animal model for infectious disease research

James R Swearengen  1
Affiliations
Review

Choosing the right animal model for infectious disease research

James R Swearengen. Animal Model Exp Med. .

Abstract

A complex biological system is often required to study the myriad of host-pathogen interactions associated with infectious diseases, especially since the current basis of biology has reached the molecular level. The use of animal models is important for understanding the very complex temporal relationships that occur in infectious disease involving the body, its neuroendocrine and immune systems and the infectious organism. Because of these complex interactions, the choice of animal model must be a thoughtful and clearly defined process in order to provide relevant, translatable scientific data and to ensure the most beneficial use of the animals. While many animals respond similarly to humans from physiological, pathological, and therapeutic perspectives, there are also significant species-by-species differences. A well-designed animal model requires a thorough understanding of similarities and differences in the responses between humans and animals and incorporates that knowledge into the goals of the study. Determining the intrinsic and extrinsic factors associated with the disease and creating a biological information matrix to compare the animal model and human disease courses is a useful tool to help choose the appropriate animal model. Confidence in the correlation of results from a model to the human disease can be achieved only if the relationship of the model to the human disease is well understood.

Keywords: animal; disease; extrinsic; fidelity; infectious; intrinsic; matrix; model; research; validity.

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Conflict of interest statement

None.

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References

    1. Institute for Laboratory Animal Research (U.S.). Committee on New and Emerging Models in Biomedical and Behavioral Research . Biomedical Models and Resources: Current Needs and Future Opportunities. Washington, DC: National Academy Press; 1998.
    1. Kriesberg N. Animals as Models. https://ori.hhs.gov/education/products/ncstate/models.htm. Accessed January 16, 2018.
    1. Quimby F. Animal models in biomedical research In: Fox JG, Anderson LC, Otto G, Pritchett‐Corning KR, Whary M, eds. Laboratory Animal Medicine. New York, NY: Academic Press; 2002:1185‐1225.
    1. National Research Council (U.S.). Committee on Models for Biomedical Research . Models for Biomedical Research: A New Perspective. Washington, DC: National Academy Press; 1985:12‐23.
    1. Hau J. Animal models for human disease In: Conn MP, ed. Sourcebook of Models for Biomedical Research. Totowa, NJ: Humana Press; 2008:3‐8.