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. 2019 Apr;25(4):784-787.
doi: 10.3201/eid2504.180958.

Early Genomic Detection of Cosmopolitan Genotype of Dengue Virus Serotype 2, Angola, 2018

Sarah C Hill, Jocelyne Neto de Vasconcelos, Bernardo Gutierrez Granja, Julien Thézé, Domingos Jandondo, Zoraima Neto, Marinela Mirandela, Cruz Dos Santos Sebastião, Ana Luísa Micolo Cândido, Carina Clemente, Sara Pereira da Silva, Túlio de Oliveira, Oliver G Pybus, Nuno R Faria, Joana Morais Afonso

Early Genomic Detection of Cosmopolitan Genotype of Dengue Virus Serotype 2, Angola, 2018

Sarah C Hill et al. Emerg Infect Dis. 2019 Apr.

Abstract

We used portable genome sequencing to investigate reported dengue virus transmission in Angola. Our results show that autochthonous transmission of dengue serotype 2 (cosmopolitan genotype) occurred in January 2018.

Keywords: Angola; DENV; arboviruses; dengue; dengue virus; epidemiologic surveillance; genomic detection; mosquito-borne diseases; nanopore sequencing; vector-borne infections; viruses.

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Figures

Figure
Figure
Investigation of DENV infections in Luanda, Angola, January 1, 2016–May 15, 2018. A) Number of DENV infections (i.e., cases positive for DENV NS1), Luanda, Angola, May 1, 2017–May 15, 2018. B) Midpoint rooted maximum-likelihood phylogeny of DENV-2 whole genomes. Support for branching structure is shown by bootstrap values at nodes. On the right side, the cosmopolitan genotype clade containing the Angola DENV-2 sequence is expanded. Colors indicate geographic location of sampling. The Angola DENV-2 is shown in bold. Support for branching structure is shown by bootstrap values at nodes (bootstrap scores >70 shown). C) Geographic distribution of available DENV-2 sequence data (>100 bp). Pie chart radii are log-proportional to the number of sequences available in each country and are colored according to genotype DENV, dengue virus; DENV-2, dengue virus serotype 2; NS1, nonstructural protein 1; SE, Southeast; seq, sequences; und, undefined.
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