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. 2019 May;78(5):590-593.
doi: 10.1136/annrheumdis-2018-214514. Epub 2019 Feb 13.

Prevotella copri in individuals at risk for rheumatoid arthritis

Deshire Alpizar-Rodriguez  1 , Till Robin Lesker  2 , Achim Gronow  2 , Benoît Gilbert  1 , Elena Raemy  1 , Celine Lamacchia  1 , Cem Gabay  1 , Axel Finckh #  3 , Till Strowig #  4   5
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Prevotella copri in individuals at risk for rheumatoid arthritis

Deshire Alpizar-Rodriguez et al. Ann Rheum Dis. 2019 May.

Abstract

Objectives: Rheumatoid arthritis (RA) has been associated with a relative expansion of faecal Prevotellaceae. To determine the microbiome composition and prevalence of Prevotella spp. in a group of individuals at increased risk for RA, but prior to the development of the disease.

Methods: In an ongoing cohort study of first-degree relatives (FDRs) of patients with RA, we identified 'FDR controls', asymptomatic and without autoantibodies, and individuals in pre-clinical RA stages, who had either developed anticitrullinated peptide antibodies or rheumatoid factor positivity and/or symptoms and signs associated with possible RA. Stool sampling and culture-independent microbiota analyses were performed followed by descriptive statistics and statistical analyses of community structures.

Results: A total of 133 participants were included, of which 50 were categorised as 'FDR controls' and 83 in 'pre-clinical RA stages'. The microbiota of individuals in 'pre-clinical RA stages' was significantly altered compared with FDR controls. We found a significant enrichment of the bacterial family Prevotellaceae, particularly Prevotella spp., in the 'pre-clinical RA' group (p=0.04).

Conclusions: Prevotella spp. enrichment in individuals in pre-clinical stages of RA, before the onset of RA, suggests a role of intestinal dysbiosis in the development of RA.

Keywords: epidemiology of ra; microbiome; pre-clinical stages of ra; rheumatoid arthritis.

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Conflict of interest statement

Competing interests: None declared.

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