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Review
. 2019 Apr:491:39-45.
doi: 10.1016/j.cca.2019.01.011. Epub 2019 Jan 14.

Ki-67 protein as a tumour proliferation marker

Sunil Sankunny Menon  1 , Chandrasekharan Guruvayoorappan  2 , Kunnathur Murugesan Sakthivel  3 , Rajan Radha Rasmi  4
Affiliations
Review

Ki-67 protein as a tumour proliferation marker

Sunil Sankunny Menon et al. Clin Chim Acta. 2019 Apr.

Abstract

Newer treatment strategy based on proliferative nuclear marker Ki-67 targeted therapy holds promise for prioritized/personalized treatment options with regard to improved survival and outcome in patients with renal cancer. Over the past decade, the importance of Ki-67 in prognosis of breast cancer has been widely studied, however very few studies and literatures are available in the context of renal cancer which has an increasing incidence internationally. The focus of this present review is to fill the gaps pertaining to its prognosis and management with newly understood mechanisms of targeted interventions. Recent breakthrough discoveries have highlighted the correlation of Ki-67 expression to stage and metastatic potential in renal tumours. A better understanding of molecular structure and different protein domains along with its regulation will provide evidence for precise target thereby controlling the proliferation rate correlated with decrease in the Ki-67 protein levels. Therapies targeting Ki-67 is still in the preclinical stage, besides its diagnostic and/or prognostic significance, a better understanding of targeted strategical studies is required for extrapolation to the clinical use. Current understanding of the associated molecular pathways and the precise role of Ki-67 could streamline the basis for predicting renal cancer outcome.

Keywords: Breast cancer; Diagnosis; Ki-67; Proliferation; Renal cancer; Targeted therapy.

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