An updated review of adipose derived-mesenchymal stem cells and their applications in musculoskeletal disorders

doi:10.1080/14712598.2019.1563069

Review

. 2019 Mar;19(3):233-248.

doi: 10.1080/14712598.2019.1563069. Epub 2019 Jan 25.

An updated review of adipose derived-mesenchymal stem cells and their applications in musculoskeletal disorders

Mario Rivera-Izquierdo¹, Laura Cabeza^{1

2

3}, Antonio Láinez-Ramos-Bossini^{3

4}, Raul Quesada^{1

2

3}, Gloria Perazzoli², Pablo Alvarez², Jose Prados^{1

2

3}, Consolación Melguizo^{1

2

3}

Affiliations

¹ a Department of Anatomy and Embryology, Faculty of Medicine , University of Granada , Granada , Spain.
² b Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM) , University of Granada , Granada , Spain.
³ c Biosanitary Institute of Granada (IBS GRANADA) , SAS -Universidad de Granada , Granada , Spain.
⁴ d Department of Radiology , Hospital Universitario Virgen de las Nieves , Granada , Spain.

PMID: 30653367
DOI: 10.1080/14712598.2019.1563069

Review

An updated review of adipose derived-mesenchymal stem cells and their applications in musculoskeletal disorders

Mario Rivera-Izquierdo et al. Expert Opin Biol Ther. 2019 Mar.

. 2019 Mar;19(3):233-248.

doi: 10.1080/14712598.2019.1563069. Epub 2019 Jan 25.

Authors

Affiliations

¹ a Department of Anatomy and Embryology, Faculty of Medicine , University of Granada , Granada , Spain.
² b Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM) , University of Granada , Granada , Spain.
³ c Biosanitary Institute of Granada (IBS GRANADA) , SAS -Universidad de Granada , Granada , Spain.
⁴ d Department of Radiology , Hospital Universitario Virgen de las Nieves , Granada , Spain.

PMID: 30653367
DOI: 10.1080/14712598.2019.1563069

Abstract

Introduction: Adipose-derived mesenchymal stem cells (ASCs) represent a new therapeutic strategy in biomedicine with many potential applications, especially in musculoskeletal disorders. Preclinical and clinical studies based on the administration of ASCs support their efficacy in bone regeneration, joint repair, tendon injury and skeletal muscle alterations. Many of these novel treatments may improve patients' quality of life and prognosis. However, several concerns about the use of stem cells remain unsolved, particularly regarding their safety and side effects. The present work aims to review the nature, clinical trials and patents involving the use of ASCs in musculoskeletal disorders.

Areas covered: In this article, we describe ASCs' isolation, culture and differentiation in vivo and in vitro, advances on ASCs' applications in bone, cartilage, muscle and tendon repair, and patents involving the use of ASCs.

Expert opinion: The use of ASCs in musculoskeletal disorders presents significant therapeutic advantages, including limited autoimmune response, potential cell expansion ex vivo, high plasticity to differentiate into several mesodermal cell lineages, and additional effects of therapeutic interest such as secretion of neurotrophic factors and anti-inflammatory properties. For these reasons, ASCs are promising therapeutic agents for clinical applications in musculoskeletal disorders.

Keywords: Mesenchymal stem cells; bone; cartilage; clinical trials; muscle; musculoskeletal disorders; patents.

PubMed Disclaimer

Cited by

Allogenic Adipose Tissue-Derived Stromal/Stem Cells and Vitamin D Supplementation in Patients With Recent-Onset Type 1 Diabetes Mellitus: A 3-Month Follow-Up Pilot Study.
Araujo DB, Dantas JR, Silva KR, Souto DL, Pereira MFC, Moreira JP, Luiz RR, Claudio-Da-Silva CS, Gabbay MAL, Dib SA, Couri CEB, Maiolino A, Rebelatto CLK, Daga DR, Senegaglia AC, Brofman PRS, Baptista LS, Oliveira JEP, Zajdenverg L, Rodacki M. Araujo DB, et al. Front Immunol. 2020 Jun 2;11:993. doi: 10.3389/fimmu.2020.00993. eCollection 2020. Front Immunol. 2020. PMID: 32582156 Free PMC article. Clinical Trial.
Molecular mechanism underlying miR-204-5p regulation of adipose-derived stem cells differentiation into cells from three germ layers.
Wang Z, Bi M, Zhe X, Wang X, Dai B, Han X, Ren B, Liang H, Liu D. Wang Z, et al. Cell Death Discov. 2024 Feb 22;10(1):95. doi: 10.1038/s41420-024-01852-4. Cell Death Discov. 2024. PMID: 38388551 Free PMC article.
Advances of adipose-derived mesenchymal stem cells-based biomaterial scaffolds for oral and maxillofacial tissue engineering.
Liu T, Xu J, Pan X, Ding Z, Xie H, Wang X, Xie H. Liu T, et al. Bioact Mater. 2021 Jan 30;6(8):2467-2478. doi: 10.1016/j.bioactmat.2021.01.015. eCollection 2021 Aug. Bioact Mater. 2021. PMID: 33553828 Free PMC article. Review.
Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review.
Itro A, Trotta MC, Miranda R, Paoletta M, De Cicco A, Lepre CC, Tarantino U, D'Amico M, Toro G, Schiavone Panni A. Itro A, et al. Pharmaceutics. 2022 May 27;14(6):1151. doi: 10.3390/pharmaceutics14061151. Pharmaceutics. 2022. PMID: 35745724 Free PMC article. Review.
Basic fibroblast growth factor enhances proliferation and hepatocyte growth factor expression of feline mesenchymal stem cells.
Fujimoto Y, Yokozeki T, Yokoyama A, Tabata Y. Fujimoto Y, et al. Regen Ther. 2020 May 26;15:10-17. doi: 10.1016/j.reth.2020.03.013. eCollection 2020 Dec. Regen Ther. 2020. PMID: 32490062 Free PMC article.

See all "Cited by" articles

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Atypon

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

An updated review of adipose derived-mesenchymal stem cells and their applications in musculoskeletal disorders

Affiliations

An updated review of adipose derived-mesenchymal stem cells and their applications in musculoskeletal disorders

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources