Viral threat to male fertility
- PMID: 30569651
- DOI: 10.1111/and.13140
Viral threat to male fertility
Abstract
The detrimental effects of Zika virus (ZIKV) infection on mouse testicular functions have reminded a viral threat to male fertility. A broad range of virus families has tropism for male reproductive system, particularly the testes. Certain virus types of these viruses, such as mumps virus and human immunodeficiency virus (HIV), may severely damage the testes and consequently lead to male infertility. ZIKV has been recently found to damage testicular functions and lead to male infertility in mice. Many other viruses also have detrimental effects on host reproduction. Public attention has been paid to sexually transmitted viruses, such as HIV and hepatitis B and C viruses in humans and likewise in economically important farm animals. This article provides an overview on main viruses affecting the male reproductive system and their detrimental effects on fertility, and outlines some important issues for future study.
Keywords: Zika virus; infertility; male reproduction; orchitis; viral infection.
© 2018 Blackwell Verlag GmbH.
Similar articles
-
A new threat to human reproduction system posed by Zika virus (ZIKV): From clinical investigations to experimental studies.Virus Res. 2018 Aug 2;254:10-14. doi: 10.1016/j.virusres.2017.09.005. Epub 2017 Sep 8. Virus Res. 2018. PMID: 28893652 Review.
-
Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice.Cell. 2016 Dec 1;167(6):1511-1524.e10. doi: 10.1016/j.cell.2016.11.016. Epub 2016 Nov 21. Cell. 2016. PMID: 27884405
-
Zika virus and reproduction: facts, questions and current management.Hum Reprod Update. 2017 Nov 1;23(6):629-645. doi: 10.1093/humupd/dmx024. Hum Reprod Update. 2017. PMID: 28961800 Review.
-
Pathogenesis and sexual transmission of Spondweni and Zika viruses.PLoS Negl Trop Dis. 2017 Oct 6;11(10):e0005990. doi: 10.1371/journal.pntd.0005990. eCollection 2017 Oct. PLoS Negl Trop Dis. 2017. PMID: 28985234 Free PMC article.
-
Sertoli Cells Are Susceptible to ZIKV Infection in Mouse Testis.Front Cell Infect Microbiol. 2017 Jun 21;7:272. doi: 10.3389/fcimb.2017.00272. eCollection 2017. Front Cell Infect Microbiol. 2017. PMID: 28680856 Free PMC article.
Cited by
-
Stage-specific expression of Toll-like receptors in the seminiferous epithelium of mouse testis.Histochem Cell Biol. 2024 Oct;162(4):323-335. doi: 10.1007/s00418-024-02310-z. Epub 2024 Jul 31. Histochem Cell Biol. 2024. PMID: 39085445 Free PMC article.
-
Investigating the effects of the Omicron variant of COVID-19 on sperm parameters and serum levels of male sexual hormones: Prospective observational study.New Microbes New Infect. 2024 May 15;60-61:101432. doi: 10.1016/j.nmni.2024.101432. eCollection 2024 Aug-Oct. New Microbes New Infect. 2024. PMID: 38800713 Free PMC article.
-
The impact of COVID-19 on male reproductive health: a Systematic Review.JBRA Assist Reprod. 2024 Aug 26;28(3):483-488. doi: 10.5935/1518-0557.20240028. JBRA Assist Reprod. 2024. PMID: 38712833 Free PMC article.
-
Systematic analyses of the factors influencing sperm quality in patients with SARS-CoV-2 infection.Sci Rep. 2024 Apr 7;14(1):8132. doi: 10.1038/s41598-024-58797-y. Sci Rep. 2024. PMID: 38584153 Free PMC article.
-
Update on known and emergent viruses affecting human male genital tract and fertility.Basic Clin Androl. 2024 Mar 14;34(1):6. doi: 10.1186/s12610-024-00222-5. Basic Clin Androl. 2024. PMID: 38486154 Free PMC article. Review.
Publication types
MeSH terms
Grants and funding
LinkOut - more resources
Full Text Sources
Medical