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Review
. 2019 Feb:106:7-16.
doi: 10.1016/j.yexmp.2018.11.010. Epub 2018 Nov 22.

Long non-coding RNAs and cervical cancer

Hamid Aalijahan  1 , Saeid Ghorbian  2
Affiliations
Review

Long non-coding RNAs and cervical cancer

Hamid Aalijahan et al. Exp Mol Pathol. 2019 Feb.

Abstract

Cervical cancer is determined as the second highest number of deaths factor in female cancers. Here is a need to find new biomarkers for detection and preliminary prognosis, metastasis. To find new treatment to enhance the survival of cervical cancer patients, pivotal actions are necessitated to be implemented. Long non-coding RNAs (lncRNAs) appear to be the crucial modulators in various processes and critically influence the oncogenesis. The commencement and general review actions of the following lncRNAs HOTAIR, H19, XIST, CCHE1, EBIC, MALAT1, ANRIL, LET, NEAT1, BLACAT1, UFC1, SNHG16 and SNHG20 are focused in this review article. Roles of the lncRNAs in cervical cancer in terms of prognosis and tumor progression, invasion and metastasis, apoptosis, and radio-resistance are pointed out. In this review the utilization of lncRNAs as biomarkers in cervical cancer prognosis for metastasis is discussed. An overview of this review will be useful for selection of biomarkers in diagnosis, prognosis, and targeted therapy of cervical cancer in the future.

Keywords: Biomarker; Cervical cancer; HOTAIR; LncRNAs; Prognosis.

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