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. 1987 Sep;55(9):2088-92.
doi: 10.1128/iai.55.9.2088-2092.1987.

Oxidative killing of Aspergillus fumigatus proceeds by parallel myeloperoxidase-dependent and -independent pathways

R G Washburn, J I Gallin, J E Bennett

Oxidative killing of Aspergillus fumigatus proceeds by parallel myeloperoxidase-dependent and -independent pathways

R G Washburn et al. Infect Immun. 1987 Sep.

Abstract

The relative importance of several oxygen intermediates in fungicidal action against opsonized Aspergillus fumigatus conidia was investigated with monocytes from normal volunteers and patients with either chronic granulomatous disease or myeloperoxidase (MPO) deficiency. Results from experiments in which catalase, taurine, mannitol, or glucose-glucose oxidase were added to these phagocytes indicated that the MPO-hydrogen peroxide-halide system and an MPO-independent oxidative system exerted comparable conidiacidal activity. These findings offer a plausible explanation for the susceptibility of patients with chronic granulomatous disease to invasive Aspergillus infections; their phagocytes fail to generate hydrogen peroxide, a substrate necessary for both systems. Patients with MPO deficiency are not known to be predisposed to invasive aspergillosis, suggesting that an MPO-independent oxidative system may provide an alternative mechanism for the oxidative killing of Aspergillus spp.

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References

    1. J Infect Dis. 1983 Mar;147(3):474-83 - PubMed
    1. J Clin Invest. 1977 Dec;60(6):1266-79 - PubMed
    1. Blood. 1986 Apr;67(4):1132-8 - PubMed
    1. Int Arch Allergy Appl Immunol. 1984;73(3):231-6 - PubMed
    1. Infect Immun. 1986 Mar;51(3):731-5 - PubMed