doi: 10.1021/acs.orglett.8b03173.
Epub 2018 Nov 2.
Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus
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- PMID: 30388018
- DOI: 10.1021/acs.orglett.8b03173
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Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus
Org Lett.
.
Abstract
An efficient synthesis of grazoprevir is reported. Starting from four readily available building blocks, grazoprevir is prepared in 51% overall yield and >99.9% purity for pharmaceutical use.
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