doi: 10.1038/328221a0.
Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family
- PMID: 3037384
- DOI: 10.1038/328221a0
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Sequence and functional expression of the GABA A receptor shows a ligand-gated receptor super-family
Nature.
1987 Jul.
Abstract
Amino-acid sequences derived from complementary DNAs encoding the alpha- and beta-subunits of the GABA/benzodiazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors. Co-expression of the in vitro-generated alpha-subunit and beta-subunit RNAs in Xenopus oocytes produces a functional receptor and ion channel with the pharmacological properties characteristic of the GABAA receptor.
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