doi: 10.1093/nar/15.8.3305.
All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs
- PMID: 3033601
- PMCID: PMC340731
- DOI: 10.1093/nar/15.8.3305
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All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs
Nucleic Acids Res.
.
Free PMC article
Abstract
Translation of the foot and mouth disease virus genome in vitro and in vivo indicated that all seven serotypes initiate protein synthesis at two separate AUGs. Sequence analysis of the region surrounding these AUGs has shown that the efficiency with which the initiating AUG is recognized is dependent on the flanking nucleotides. However, in vitro, the major factor determining which AUG is used is the concentration of Mg2+.
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