Membrane tethering by the autophagy ATG2A-WIPI4 complex

doi:10.1073/pnas.1814759115

Comment

. 2018 Oct 16;115(42):10540-10541.

doi: 10.1073/pnas.1814759115. Epub 2018 Oct 1.

Membrane tethering by the autophagy ATG2A-WIPI4 complex

Martin Graef^{1

2}

Affiliations

¹ Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany; martin.graef@age.mpg.de.
² Cologne Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany.

PMID: 30275332
PMCID: PMC6196487
DOI: 10.1073/pnas.1814759115

Comment

Membrane tethering by the autophagy ATG2A-WIPI4 complex

Martin Graef. Proc Natl Acad Sci U S A. 2018.

. 2018 Oct 16;115(42):10540-10541.

doi: 10.1073/pnas.1814759115. Epub 2018 Oct 1.

Author

Martin Graef^{1

2}

Affiliations

¹ Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany; martin.graef@age.mpg.de.
² Cologne Cluster of Excellence on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, 50931 Cologne, Germany.

PMID: 30275332
PMCID: PMC6196487
DOI: 10.1073/pnas.1814759115

No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Figures

**Fig. 1.**
The ATG2-Atg18/WIPI complex may tether forming autophagosomes (IM) to the ER and facilitate lipid transport.

See this image and copyright information in PMC

Comment on

Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex.
Chowdhury S, Otomo C, Leitner A, Ohashi K, Aebersold R, Lander GC, Otomo T. Chowdhury S, et al. Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):E9792-E9801. doi: 10.1073/pnas.1811874115. Epub 2018 Sep 5. Proc Natl Acad Sci U S A. 2018. PMID: 30185561 Free PMC article.

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References

1. Lamb CA, Yoshimori T, Tooze SA. The autophagosome: Origins unknown, biogenesis complex. Nat Rev Mol Cell Biol. 2013;14:759–774. - PubMed
1. Kraft C, Martens S. Mechanisms and regulation of autophagosome formation. Curr Opin Cell Biol. 2012;24:496–501. - PubMed
1. Graef M, Friedman JR, Graham C, Babu M, Nunnari J. ER exit sites are physical and functional core autophagosome biogenesis components. Mol Biol Cell. 2013;24:2918–2931. - PMC - PubMed
1. Böckler S, Westermann B. Mitochondrial ER contacts are crucial for mitophagy in yeast. Dev Cell. 2014;28:450–458. - PubMed
1. Hamasaki M, et al. Autophagosomes form at ER-mitochondria contact sites. Nature. 2013;495:389–393. - PubMed

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[1] Lamb CA, Yoshimori T, Tooze SA. The autophagosome: Origins unknown, biogenesis complex. Nat Rev Mol Cell Biol. 2013;14:759–774. - PubMed

[2] Lamb CA, Yoshimori T, Tooze SA. The autophagosome: Origins unknown, biogenesis complex. Nat Rev Mol Cell Biol. 2013;14:759–774. - PubMed

[3] Kraft C, Martens S. Mechanisms and regulation of autophagosome formation. Curr Opin Cell Biol. 2012;24:496–501. - PubMed

[4] Kraft C, Martens S. Mechanisms and regulation of autophagosome formation. Curr Opin Cell Biol. 2012;24:496–501. - PubMed

[5] Graef M, Friedman JR, Graham C, Babu M, Nunnari J. ER exit sites are physical and functional core autophagosome biogenesis components. Mol Biol Cell. 2013;24:2918–2931. - PMC - PubMed

[6] Graef M, Friedman JR, Graham C, Babu M, Nunnari J. ER exit sites are physical and functional core autophagosome biogenesis components. Mol Biol Cell. 2013;24:2918–2931. - PMC - PubMed

[7] Böckler S, Westermann B. Mitochondrial ER contacts are crucial for mitophagy in yeast. Dev Cell. 2014;28:450–458. - PubMed

[8] Böckler S, Westermann B. Mitochondrial ER contacts are crucial for mitophagy in yeast. Dev Cell. 2014;28:450–458. - PubMed

[9] Hamasaki M, et al. Autophagosomes form at ER-mitochondria contact sites. Nature. 2013;495:389–393. - PubMed

[10] Hamasaki M, et al. Autophagosomes form at ER-mitochondria contact sites. Nature. 2013;495:389–393. - PubMed

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Membrane tethering by the autophagy ATG2A-WIPI4 complex

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Membrane tethering by the autophagy ATG2A-WIPI4 complex

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