Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018:51:261-264.
doi: 10.1016/j.ijscr.2018.09.005. Epub 2018 Sep 10.

Differential diagnosis of solitary gastric Peutz-Jeghers-type polyp with stomach cancer: a case report

Nao Yoshizawa  1 , Hirokazu Yamaguchi  2 , Michio Kaminishi  2
Affiliations

Differential diagnosis of solitary gastric Peutz-Jeghers-type polyp with stomach cancer: a case report

Nao Yoshizawa et al. Int J Surg Case Rep. 2018.

Abstract

Introduction: Solitary Peutz-Jeghers-type polyps of the stomach are extremely rare. They are defined as unique polyps that are not associated with Peutz-Jeghers syndrome (PJS).

Presentation of case: A 37-year-old woman presented at our hospital with anemia and epigastric discomfort. Esophagogastroduodenoscopy to determine the cause of anemia revealed a 5 × 6-cm pedunculated polypoid tumor at the greater curvature of the upper gastric body. Pathological examination of a biopsy specimen confirmed a Group 1 hyperplastic polyp. Computed tomography revealed neither lymph node swelling nor distant metastasis. A malignant component of the polypoid tumor was difficult to deny because of its size. The patient underwent local resection of the stomach. Her postoperative course was uneventful. A pathological examination of the surgical specimen revealed a Peutz-Jeghers-type, hamartomatous polyp containing an enlarged crypt with hyperplastic foveolar epithelium and smooth muscle proliferating into the lamina propria. No atypical cells were found in the overlying epithelium. Based on these findings, we performed colonoscopy and capsule endoscopy of the intestine. No polyps were found in the intestine or colon. She had no family history of any type of tumor and no mucocutaneous pigmentation.

Discussion: There were only 10 reports of solitary gastric Peutz-Jeghers polyps published to date. Although most of them did not have atypical cells, one case has proliferative component. A few reports have described relationship with malignant tumor.

Conclusion: Solitary gastric PJ-type polyps are rare. Careful follow-up should be recommended and further studies are needed to evaluate cancer risk of solitary gastric PJ-type polyps.

Keywords: Solitary peutz-jeghers-type polyps; Sporadic hamartomatous polyps; Stomach.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Esophagogastroduodenoscopy findings. Images show a semi-pedunculated, 5 × 6-cm polypoid tumor in the greater curvature of the upper gastric body (a, b).
Fig. 2
Fig. 2
Computed tomography findings. Images show tumor located around the border of fornix and upper body of stomach (a), and stalk-like structure at root of the polyp (b).
Fig. 3
Fig. 3
Pathological findings. Foveolar hyperplasia on polyp surface (a; magnification ×20) and cystically dilated glands (b, magnification ×40). Cells at the base of glands are similar to those in fundic glands (c). Desmin staining shows arborizing smooth muscle bundles extending up to the superficial lamina propria (d).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Agha R.A., Fowler A.J., Saeta A. The SCARE statement: consensus-based surgical case report guidelines. Int. J. Surg. 2016;34:180–186. - PubMed
    1. Cauchin E., Touchefeu Y., Matysiak-Budnik T. Hamartomatous Tumors in the Gastrointestinal Tract. Gastrointest. Tumors. 2015;2:65–74. - PMC - PubMed
    1. Calva D., Howe J.R. Hamartomatous polyposis syndromes. Surg. Clin. North Am. 2008;88:779–817. vii. - PMC - PubMed
    1. Zbuk K.M., Eng C. Hamartomatous polyposis syndromes. Nat. Clin. Pract. Gastroenterol. Hepatol. 2007;4:492–502. - PubMed
    1. Utsunomiya J., Gocho H., Miyanaga T. Peutz-Jeghers syndrome: its natural course and management. Johns Hopkins Med. J. 1975;136:71–82. - PubMed